C3(-/-)

eagle-i ID

Resource Type

Properties

1. Resource Description

   C57BL/6-C3^−/− (G6 backcross) from Dr. Rick Wetsel (University of Texas Health Sciences Center at Houston) were further backcrossed in-house. In the C3 gene: "A genomic fragment containing 2.3 kb of the 5' flanking region and the first 105 bp of exon 1 was replaced with a neomycin selection cassette." This strain is cryo-preserved.

2. Related Publication or Documentation

   Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury

3. Related Publication or Documentation

   The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo

4. Related Publication or Documentation

   Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice

5. Related Publication or Documentation

   Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

6. Related Publication or Documentation

   Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg

7. Related Publication or Documentation

   Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor

8. Related Publication or Documentation

   Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack

9. Website(s)

   http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=5995

10. Parental Strain Name

    C57BL/6

11. Biological process studied

    Immune system process

12. Genetic Alteration(s)

    C3[tm1Hrc]

13. Phenotype Findings

    Protection against K/BxN mouse serum induced arthritis

14. Phenotype Findings

    Normal cytokine level

15. Phenotype Findings

    Abnormal erythrocyte clearance

16. Phenotype Findings

    Abnormal complement protein level

17. Phenotype Findings

    Response to antigen restimulation

18. Phenotype Findings

    Experimental autoimmune encephalomyelitis phenotype

19. Location

    Wen-Chao Song Laboratory