C4(-/-)

eagle-i ID

Resource Type

Properties

1. Exchange facilitator

   <a href=http://jaxmice.jax.org/strain/003643.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>

2. Resource Description

   C4 knockout (C4^−/−) mice were from The Jackson Laboratory (Bar Harbor, ME). "A genomic fragment corresponding to 987 nucleotides of coding sequence (exons 23-29) was replaced with a neomycin selection cassette." This strain is cryo-preserved.

3. Related Publication or Documentation

   Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice

4. Related Publication or Documentation

   Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg

5. Related Publication or Documentation

   Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor

6. Website(s)

   http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=2775

7. Parental Strain Name

   C57BL/6

8. Biological process studied

   Immune system process

9. Genetic Alteration(s)

   C4b[tm1Crr]

10. Phenotype Findings

    Abnormal complement protein level

11. Phenotype Findings

    Normal complement alternative pathway

12. Phenotype Findings

    Accelerated clearance of DAF/Crry-deficient platelets

13. Location

    Wen-Chao Song Laboratory