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C4(-/-)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-5825-0702-2f2e-ad3380000000

Resource Type

  1. Mus musculus

Properties

  1. Exchange facilitator
    <a href=http://jaxmice.jax.org/strain/003643.html target=_window><img src=https://eagle-i.net/images/jacksonlabs-button-large.png alt='Order from Jackson Laboratory'></a>
  2. Resource Description
    C4 knockout (C4<sup>−/−</sup>) mice were from The Jackson Laboratory (Bar Harbor, ME). "A genomic fragment corresponding to 987 nucleotides of coding sequence (exons 23-29) was replaced with a neomycin selection cassette." This strain is cryo-preserved.
  3. Related Publication or Documentation
    Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
  4. Related Publication or Documentation
    Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
  5. Related Publication or Documentation
    Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor
  6. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=2775
  7. Parental Strain Name
    C57BL/6
  8. Biological process studied
    Immune system process
  9. Genetic Alteration(s)
    C4b[tm1Crr]
  10. Phenotype Findings
    Abnormal complement protein level
  11. Phenotype Findings
    Normal complement alternative pathway
  12. Phenotype Findings
    Accelerated clearance of DAF/Crry-deficient platelets
  13. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow owner
    fcoldren
  2. workflow state
    Published
  3. contributor
    fcoldren
  4. created
    2013-04-29T19:33:52.901-04:00
  5. creator
    fcoldren
  6. modified
    2016-02-15T12:56:11.965-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016