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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    Exons 3 through 7 of the complement factor B gene (<i>Cfb</i>) were replaced with a neomycin resistance cassette. This strain is cryo-preserved.
  2. Additional Name
  3. Additional Name
    Factor B KO
  4. Access Restriction(s)
    MTA restrictions
  5. Related Publication or Documentation
    Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
  6. Related Publication or Documentation
    Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement
  7. Related Publication or Documentation
    Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
  8. Related Publication or Documentation
    Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack
  9. Related Publication or Documentation
    Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack
  10. Related Publication or Documentation
    Abrogation of the alternative complement pathway by targeted deletion of murine factor B
  11. Website(s)
  12. Parental Strain Name
  13. Biological process studied
    Immune system process
  14. Genetic Alteration(s)
  15. Phenotype Findings
    Impaired complement classical pathway
  16. Phenotype Findings
    Impaired complement alternative pathway
  17. Phenotype Findings
    Abnormal complement protein level
  18. Location
    Wen-Chao Song Laboratory
Provenance Metadata About This Resource Record
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  2. contributor
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016