eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

fB(-/-)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-5825-5138-2f2e-ad3380000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Exons 3 through 7 of the complement factor B gene (<i>Cfb</i>) were replaced with a neomycin resistance cassette. This strain is cryo-preserved.
  2. Additional Name
    Bf(-/-)
  3. Additional Name
    Factor B KO
  4. Access Restriction(s)
    MTA restrictions
  5. Related Publication or Documentation
    Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
  6. Related Publication or Documentation
    Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement
  7. Related Publication or Documentation
    Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
  8. Related Publication or Documentation
    Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack
  9. Related Publication or Documentation
    Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack
  10. Related Publication or Documentation
    Abrogation of the alternative complement pathway by targeted deletion of murine factor B
  11. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=2513
  12. Parental Strain Name
    C57BL/6
  13. Biological process studied
    Immune system process
  14. Genetic Alteration(s)
    Cfb[tm1Hrc]
  15. Phenotype Findings
    Impaired complement classical pathway
  16. Phenotype Findings
    Impaired complement alternative pathway
  17. Phenotype Findings
    Abnormal complement protein level
  18. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-04-29T19:34:11.940-04:00
  4. creator
    fcoldren
  5. modified
    2016-02-17T17:23:59.207-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016