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DAF(-/-)
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013e-5c0a-fce8-2f2e-ad3380000000
Resource Type
Mus musculus
Properties
Exchange facilitator
http://www.mmrrc.org/catalog/sds.php?mmrrc_id=30201
Resource Description
Mice were generated by gene targeting. "Exons 2 and 3, encoding the first and second short consensus repeats, were replaced with a neomycin selection cassette." This strain is cryo-preserved.
Additional Name
CD55<sup>-/-</sup>
Additional Name
DAF KO
Additional Name
DAF1<sup>-/-</sup>
Related Disease
glomerulonephritis
Related Publication or Documentation
Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
Related Publication or Documentation
Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice
Related Publication or Documentation
Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting
Related Publication or Documentation
The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo
Related Publication or Documentation
Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells
Related Publication or Documentation
Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
Related Publication or Documentation
Critical protection from renal ischemia reperfusion injury by CD55 and CD59
Related Publication or Documentation
Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack
Related Publication or Documentation
Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice
Related Publication or Documentation
The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice
Related Publication or Documentation
Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo
Related Publication or Documentation
Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
Related Publication or Documentation
Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor
Related Publication or Documentation
Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack
Related Publication or Documentation
Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity
Related Publication or Documentation
CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice
Related Publication or Documentation
Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry
Related Publication or Documentation
DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity
Related Publication or Documentation
Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack
Related Publication or Documentation
Characterization of glycosylphosphatidylinositol-anchored decay accelerating factor (GPI-DAF) and transmembrane DAF gene expression in wild-type and GPI-DAF gene knockout mice using polyclonal and monoclonal antibodies with dual or single specificity
Related Publication or Documentation
Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis
Website(s)
http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=8616
Parental Strain Name
C57BL/6
Biological process studied
Immune system process
Genetic Alteration(s)
CD55[tm1Song]
Phenotype Findings
Abnormal complement pathway
Phenotype Findings
Immune system phenotype
Phenotype Findings
Impaired complement classical pathway
Phenotype Findings
Impaired complement alternative pathway
Phenotype Findings
Hematopoietic system phenotype
Phenotype Findings
Increased susceptibility to experimental autoimmune myasthenia gravis
Phenotype Findings
Decreased grip strength
Phenotype Findings
Normal phenotype
Phenotype Findings
Abnormal blood cells
Phenotype Findings
Abnormal macrophage morphology
Phenotype Findings
Response to acute LCMV infection
Phenotype Findings
Hyper T cell response to antigen restimulation
Phenotype Findings
Rescue of hyper T cell response
Phenotype Findings
Increased severity of experimental autoimmune encephalomyelitis
Phenotype Findings
Hyperresponsive to LPS challenge
Phenotype Findings
Increased susceptibility to nephrotoxic serum nephritis
Location
Wen-Chao Song Laboratory
Inferred Types from the eagle-i Ontology (
What is an ontology?
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entity
continuant
independent_continuant
material_entity
Organism
Mus <mouse, genus>
Glires
Mammalia
Chordata
Vertebrata <Metazoa>
Rodentia
Organism or Virus
Thing
Provenance Metadata About This Resource Record
workflow state
Published
contributor
fcoldren
created
2013-04-30T13:44:51.427-04:00
creator
fcoldren
modified
2016-02-17T17:15:35.205-05:00