DAF(-/-)

eagle-i ID

Resource Type

Properties

1. Exchange facilitator

   http://www.mmrrc.org/catalog/sds.php?mmrrc_id=30201

2. Resource Description

   Mice were generated by gene targeting. "Exons 2 and 3, encoding the first and second short consensus repeats, were replaced with a neomycin selection cassette." This strain is cryo-preserved.

3. Additional Name

   CD55^-/-

4. Additional Name

   DAF KO

5. Additional Name

   DAF1^-/-

6. Related Disease

   glomerulonephritis

7. Related Publication or Documentation

   Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production

8. Related Publication or Documentation

   Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice

9. Related Publication or Documentation

   Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting

10. Related Publication or Documentation

    The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo

11. Related Publication or Documentation

    Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells

12. Related Publication or Documentation

    Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice

13. Related Publication or Documentation

    Critical protection from renal ischemia reperfusion injury by CD55 and CD59

14. Related Publication or Documentation

    Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack

15. Related Publication or Documentation

    Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice

16. Related Publication or Documentation

    The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice

17. Related Publication or Documentation

    Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo

18. Related Publication or Documentation

    Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg

19. Related Publication or Documentation

    Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor

20. Related Publication or Documentation

    Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack

21. Related Publication or Documentation

    Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity

22. Related Publication or Documentation

    CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice

23. Related Publication or Documentation

    Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry

24. Related Publication or Documentation

    DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity

25. Related Publication or Documentation

    Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack

26. Related Publication or Documentation

    Characterization of glycosylphosphatidylinositol-anchored decay accelerating factor (GPI-DAF) and transmembrane DAF gene expression in wild-type and GPI-DAF gene knockout mice using polyclonal and monoclonal antibodies with dual or single specificity

27. Related Publication or Documentation

    Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis

28. Website(s)

    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=8616

29. Parental Strain Name

    C57BL/6

30. Biological process studied

    Immune system process

31. Genetic Alteration(s)

    CD55[tm1Song]

32. Phenotype Findings

    Abnormal complement pathway

33. Phenotype Findings

    Immune system phenotype

34. Phenotype Findings

    Impaired complement classical pathway

35. Phenotype Findings

    Impaired complement alternative pathway

36. Phenotype Findings

    Hematopoietic system phenotype

37. Phenotype Findings

    Increased susceptibility to experimental autoimmune myasthenia gravis

38. Phenotype Findings

    Decreased grip strength

39. Phenotype Findings

    Normal phenotype

40. Phenotype Findings

    Abnormal blood cells

41. Phenotype Findings

    Abnormal macrophage morphology

42. Phenotype Findings

    Response to acute LCMV infection

43. Phenotype Findings

    Hyper T cell response to antigen restimulation

44. Phenotype Findings

    Rescue of hyper T cell response

45. Phenotype Findings

    Increased severity of experimental autoimmune encephalomyelitis

46. Phenotype Findings

    Hyperresponsive to LPS challenge

47. Phenotype Findings

    Increased susceptibility to nephrotoxic serum nephritis

48. Location

    Wen-Chao Song Laboratory