DAF(-/-)/CD59(-/-)

eagle-i ID

Resource Type

Properties

1. Resource Description

   DAF^-/- were cross-bred with CD59^-/- mice.

2. Additional Name

   CD55(-/-)/CD59(-/-)

3. Additional Name

   DAF/CD59 d-KO

4. Related Publication or Documentation

   Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice

5. Related Publication or Documentation

   Critical protection from renal ischemia reperfusion injury by CD55 and CD59

6. Related Publication or Documentation

   Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack

7. Website(s)

   http://www.informatics.jax.org/allele/genoview/MGI:3581707?counter=7

8. Parental Strain Name

   C57BL/6

9. Biological process studied

   Immune system process

10. Genetic Alteration(s)

    CD55[tm1Song]

11. Genetic Alteration(s)

    Cd59a[tm1Song]

12. Phenotype Findings

    Increased susceptibility to kidney reperfusion injury

13. Phenotype Findings

    Abnormal complement pathway

14. Phenotype Findings

    Hematopoietic system phenotype

15. Location

    Wen-Chao Song Laboratory