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fP(-/-)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-5c15-4f53-2f2e-ad3380000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "A targeting vector was constructed where a loxP site was inserted upstream of exon 3, and a FRT flanked neomycin resistance cassette followed by a loxP site was inserted downstream of exon 5. Upon recombination, the neomycin cassette inserted in the intended location but the upstream loxP site failed to recombine. Analysis of chimeric mice revealed that the insertion of the neomycin cassette was sufficient to prevent transcription of the targeted gene. Gene inactivation was confirmed by failure to detect the gene product in the sera of homozygotes by an immunodiffusion assay." This strain is cryo-preserved.
  2. Additional Name
    Cfp(-/-)
  3. Additional Name
    Properdin KO
  4. Additional Name
    Properdin(-/-)
  5. Related Disease
    bacterial infectious disease
  6. Related Publication or Documentation
    Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury
  7. Related Publication or Documentation
    Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
  8. Related Publication or Documentation
    Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis
  9. Related Publication or Documentation
    Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement
  10. Website(s)
    http://www.informatics.jax.org/allele/key/56629
  11. Parental Strain Name
    C57BL/6-129J mix
  12. Biological process studied
    Immune system process
  13. Genetic Alteration(s)
    Cfp[tm1Song]
  14. Phenotype Findings
    Impaired complement alternative pathway
  15. Phenotype Findings
    Decreased susceptibility to induced arthritis
  16. Phenotype Findings
    Normal kidney glomeruli
  17. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-04-30T13:55:58.750-04:00
  4. creator
    fcoldren
  5. modified
    2016-06-29T17:00:00.488-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016