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eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    These mice were a gift from Dr. Hector Molina. Insertion of a neomycin resistance cassette in exon 5 resulted in mice deficient in <i>Crry</i>. Heterozygous mice, obtained from gene targeting in embryonic stem cells and blastocyst injection, were crossed with C3<sup>-/-</sup> mice and subsequently intercrossed to generate Crry<sup>-/-</sup>C3<sup>-/-</sup> mice. Crry and C3 are absent from platelets.
  2. Additional Name
  3. Related Publication or Documentation
    Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack
  4. Related Publication or Documentation
    Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement
  5. Related Publication or Documentation
    Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
  6. Related Publication or Documentation
    Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor
  7. Related Publication or Documentation
    Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack
  8. Related Publication or Documentation
    Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack
  9. Related Publication or Documentation
    A critical role for murine complement regulator crry in fetomaternal tolerance
  10. Website(s)
  11. Parental Strain Name
    mixed 129/C57BL/6
  12. Biological process studied
    Immune system process
  13. Genetic Alteration(s)
  14. Genetic Alteration(s)
  15. Phenotype Findings
    Normal survival
  16. Phenotype Findings
    Abnormal complement pathway
  17. Location
    Wen-Chao Song Laboratory
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016