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Crry(-/-)/C3(-/-)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-5c1c-67d8-2f2e-ad3380000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    These mice were a gift from Dr. Hector Molina. Insertion of a neomycin resistance cassette in exon 5 resulted in mice deficient in <i>Crry</i>. Heterozygous mice, obtained from gene targeting in embryonic stem cells and blastocyst injection, were crossed with C3<sup>-/-</sup> mice and subsequently intercrossed to generate Crry<sup>-/-</sup>C3<sup>-/-</sup> mice. Crry and C3 are absent from platelets.
  2. Additional Name
    Crl1(-/-);C3(-/-)
  3. Related Publication or Documentation
    Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack
  4. Related Publication or Documentation
    Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement
  5. Related Publication or Documentation
    Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
  6. Related Publication or Documentation
    Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor
  7. Related Publication or Documentation
    Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack
  8. Related Publication or Documentation
    Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack
  9. Related Publication or Documentation
    A critical role for murine complement regulator crry in fetomaternal tolerance
  10. Website(s)
    http://www.informatics.jax.org/allele/genoview/MGI:3505876?counter=8
  11. Parental Strain Name
    mixed 129/C57BL/6
  12. Biological process studied
    Immune system process
  13. Genetic Alteration(s)
    Cr1l[tm1Hmo]
  14. Genetic Alteration(s)
    C3[tm1Hrc]
  15. Phenotype Findings
    Normal survival
  16. Phenotype Findings
    Abnormal complement pathway
  17. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-04-30T14:03:14.785-04:00
  4. creator
    fcoldren
  5. modified
    2013-06-05T15:47:55.992-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016