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fH(m/m)
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013e-5c21-9d73-2f2e-ad3380000000
Resource Type
Properties
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Resource Description
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Two stop codons were introduced at the beginning of short consensus repeat 19 of the mouse fH gene by transfecting TL-1 embryonic stem cells with linearized targeting vector. Selected clones were used for blastocyst microinjection to produce chimeric mice. Mice were bred to homozygosity.
This strain is cryo-preserved.
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Related Disease
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glomerulonephritis
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Related Publication or Documentation
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Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis
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Parental Strain Name
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C57Bl/6-129J mix
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Genetic Alteration(s)
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Cfh with two stop codons
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Phenotype Findings
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Abnormal complement protein level
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Phenotype Findings
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Glomerular nephritis
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Phenotype Findings
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Abnormal renal glomeruli morphology
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Phenotype Findings
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C3 glomerular nephritis phenotype
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Location
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Wen-Chao Song Laboratory
