fH(m/m)

eagle-i ID

Resource Type

Properties

1. Resource Description

   Two stop codons were introduced at the beginning of short consensus repeat 19 of the mouse fH gene by transfecting TL-1 embryonic stem cells with linearized targeting vector. Selected clones were used for blastocyst microinjection to produce chimeric mice. Mice were bred to homozygosity. This strain is cryo-preserved.

2. Related Disease

   glomerulonephritis

3. Related Publication or Documentation

   Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis

4. Parental Strain Name

   C57Bl/6-129J mix

5. Genetic Alteration(s)

   Cfh with two stop codons

6. Phenotype Findings

   Abnormal complement protein level

7. Phenotype Findings

   Glomerular nephritis

8. Phenotype Findings

   Abnormal renal glomeruli morphology

9. Phenotype Findings

   C3 glomerular nephritis phenotype

10. Location

    Wen-Chao Song Laboratory