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fH(m/m)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-5c21-9d73-2f2e-ad3380000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Two stop codons were introduced at the beginning of short consensus repeat 19 of the mouse fH gene by transfecting TL-1 embryonic stem cells with linearized targeting vector. Selected clones were used for blastocyst microinjection to produce chimeric mice. Mice were bred to homozygosity. This strain is cryo-preserved.
  2. Related Disease
    glomerulonephritis
  3. Related Publication or Documentation
    Combination of factor H mutation and properdin deficiency causes severe C3 glomerulonephritis
  4. Parental Strain Name
    C57Bl/6-129J mix
  5. Genetic Alteration(s)
    Cfh with two stop codons
  6. Phenotype Findings
    Abnormal complement protein level
  7. Phenotype Findings
    Glomerular nephritis
  8. Phenotype Findings
    Abnormal renal glomeruli morphology
  9. Phenotype Findings
    C3 glomerular nephritis phenotype
  10. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-04-30T14:09:44.812-04:00
  4. creator
    fcoldren
  5. modified
    2016-02-17T17:25:14.878-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016