DAF(-/-);Crry(-/-);C3(-/-)

eagle-i ID

Resource Type

Properties

1. Resource Description

   Crry^-/-/C3^−/− and DAF^-/-/C3^−/− mice were crossed.

2. Additional Name

   CD55(-/-);Crry(-/-);C3(-/-)

3. Related Publication or Documentation

   Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack

4. Related Publication or Documentation

   Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice

5. Related Publication or Documentation

   Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor

6. Related Publication or Documentation

   Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack

7. Biological process studied

   Immune system process

8. Genetic Alteration(s)

   CD55[tm1Song]

9. Genetic Alteration(s)

   Cr1l[tm1Hmo]

10. Genetic Alteration(s)

    C3[tm1Hrc]

11. Phenotype Findings

    Abnormal complement pathway

12. Phenotype Findings

    Kidney arterial endothelial cells

13. Phenotype Findings

    Impaired complement alternative pathway

14. Location

    Wen-Chao Song Laboratory