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DAF(-/-);Crry(-/-);C3(-/-)
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/0000013e-5c24-589b-2f2e-ad3380000000
Resource Type
Mus musculus
Properties
Resource Description
Crry<sup>-/-</sup>/C3<sup>−/−</sup> and DAF<sup>-/-</sup>/C3<sup>−/−</sup> mice were crossed.
Additional Name
CD55(-/-);Crry(-/-);C3(-/-)
Related Publication or Documentation
Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack
Related Publication or Documentation
Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice
Related Publication or Documentation
Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor
Related Publication or Documentation
Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack
Biological process studied
Immune system process
Genetic Alteration(s)
CD55[tm1Song]
Genetic Alteration(s)
Cr1l[tm1Hmo]
Genetic Alteration(s)
C3[tm1Hrc]
Phenotype Findings
Abnormal complement pathway
Phenotype Findings
Kidney arterial endothelial cells
Phenotype Findings
Impaired complement alternative pathway
Location
Wen-Chao Song Laboratory
Inferred Types from the eagle-i Ontology (
What is an ontology?
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entity
continuant
independent_continuant
material_entity
Organism
Mus <mouse, genus>
Glires
Mammalia
Chordata
Vertebrata <Metazoa>
Rodentia
Organism or Virus
Thing
Provenance Metadata About This Resource Record
workflow state
Published
contributor
fcoldren
created
2013-04-30T14:12:31.883-04:00
creator
fcoldren
modified
2013-06-05T16:01:12.597-04:00