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CaMKII Cre line R4

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    CaMKII-Cre (line R4ag#11) mice were a kind gift from Dr. Ioannis Dragatsis (University of Tennessee). The construct was composed of the 8.5 kb 5' flanking calcium/calmodulin-dependent protein kinase II gene (<i>CaMKII-alpha</i>) promoter fragment, a short synthetic intron, a Cre recombinase gene containing a nuclear localization sequence, and a poly(A) addition sequence. Transgenic constructs were injected into CBA X C57BL/6J fertilized eggs and founders were crossed with C57BL/6J mice. These mice express Cre recombinase, under the control of the <i>CaMKII-alpha</i> promoter, postnatally in excitatory forebrain neurons (cortex, striatum, amygdala, hippocampal CA1 and DG).
  2. Additional Name
    <i>CaMKIIα-Cre</i> (line R4ag#11)
  3. Related Publication or Documentation
    Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments
  4. Related Publication or Documentation
    CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain
  5. Website(s)
  6. Genetic Alteration(s)
  7. Location
    Ted Abel Laboratory
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016