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CaMKII Cre line L7

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000013e-d748-c56e-5c87-8bc580000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    CaMKII-Cre (line L7ag#13) mice were a kind gift from Dr. Ioannis Dragatsis (University of Tennessee). The construct was composed of the 8.5 kb 5' flanking calcium/calmodulin-dependent protein kinase II gene (<i>CaMKII-alpha</i>) promoter fragment, a short synthetic intron, a Cre recombinase gene containing a nuclear localization sequence, and a poly(A) addition sequence. Transgenic constructs were injected into CBA X C57BL/6J fertilized eggs and founders were crossed with C57BL/6J mice. These mice express Cre recombinase, under the control of the <i>CaMKII-alpha</i> promoter, postnatally in excitatory forebrain neurons (cortex, striatum, amygdala, Hippocampal CA1, CA3, and DG). A moderate level of Cre was also detected in testis, similar to the amount of Cre in the cerebellum, at P30 and P120.
  2. Additional Name
    <i>CaMKIIα-Cre</i> (line L7ag#13)
  3. Related Publication or Documentation
    CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain
  4. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=6483
  5. Parental Strain Name
    C57BL/6
  6. Genetic Alteration(s)
    Tg(Camk2a-cre)1Szi
  7. Location
    Ted Abel Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-05-24T12:04:56.771-04:00
  4. creator
    fcoldren
  5. modified
    2013-05-28T16:14:17.953-04:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016