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CaMKII Cre line L7

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    CaMKII-Cre (line L7ag#13) mice were a kind gift from Dr. Ioannis Dragatsis (University of Tennessee). The construct was composed of the 8.5 kb 5' flanking calcium/calmodulin-dependent protein kinase II gene (<i>CaMKII-alpha</i>) promoter fragment, a short synthetic intron, a Cre recombinase gene containing a nuclear localization sequence, and a poly(A) addition sequence. Transgenic constructs were injected into CBA X C57BL/6J fertilized eggs and founders were crossed with C57BL/6J mice. These mice express Cre recombinase, under the control of the <i>CaMKII-alpha</i> promoter, postnatally in excitatory forebrain neurons (cortex, striatum, amygdala, Hippocampal CA1, CA3, and DG). A moderate level of Cre was also detected in testis, similar to the amount of Cre in the cerebellum, at P30 and P120.
  2. Additional Name
    <i>CaMKIIα-Cre</i> (line L7ag#13)
  3. Related Publication or Documentation
    CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain
  4. Website(s)
  5. Parental Strain Name
  6. Genetic Alteration(s)
  7. Location
    Ted Abel Laboratory
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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016