eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Dbh-/-

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000141-1785-ed20-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    This mouse line was generated by mating heterozygotes, and underwent targeted disruption of the dopamine β-hydroxylase gene. This resulted in complete NE/E deficiency for this mouse line, as well as retrieval deficits in spatial navigation and contextual fear.
  2. Related Publication or Documentation
    A distinct role for norepinephrine in memory retrieval
  3. Related Publication or Documentation
    Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory
  4. Related Publication or Documentation
    Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
  5. Related Publication or Documentation
    Epac signaling is required for hippocampus-dependent memory retrieval.
  6. Related Publication or Documentation
    Adrenergic signaling plays a critical role in the maintenance of waking and in the regulation of REM sleep.
  7. Related Publication or Documentation
    Postnatal development of the cerebellum and the CNS adrenergic system is independent of norepinephrine and epinephrine.
  8. Related Publication or Documentation
    Mapping neuronal activation and the influence of adrenergic signaling during contextual memory retrieval.
  9. Related Publication or Documentation
    A requirement for memory retrieval during and after long-term extinction learning.
  10. Related Publication or Documentation
    The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.
  11. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=1764
  12. Parental Strain Name
    hybrid 129/Sv × C57BL/6 background
  13. Biological process studied
    Response to stress
  14. Biological process studied
    memory
  15. Genetic Alteration(s)
    Dbh[tm1Rpa]
  16. Phenotype Findings
    Corticosterone induced impairment of memory
  17. Location
    Steven Thomas Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016