Dbh-/-

eagle-i ID

Resource Type

Properties

1. Resource Description

   This mouse line was generated by mating heterozygotes, and underwent targeted disruption of the dopamine β-hydroxylase gene. This resulted in complete NE/E deficiency for this mouse line, as well as retrieval deficits in spatial navigation and contextual fear.

2. Related Publication or Documentation

   A distinct role for norepinephrine in memory retrieval

3. Related Publication or Documentation

   Disruption of the dopamine beta-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory

4. Related Publication or Documentation

   Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.

5. Related Publication or Documentation

   Epac signaling is required for hippocampus-dependent memory retrieval.

6. Related Publication or Documentation

   Adrenergic signaling plays a critical role in the maintenance of waking and in the regulation of REM sleep.

7. Related Publication or Documentation

   Postnatal development of the cerebellum and the CNS adrenergic system is independent of norepinephrine and epinephrine.

8. Related Publication or Documentation

   Mapping neuronal activation and the influence of adrenergic signaling during contextual memory retrieval.

9. Related Publication or Documentation

   A requirement for memory retrieval during and after long-term extinction learning.

10. Related Publication or Documentation

    The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.

11. Website(s)

    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=1764

12. Parental Strain Name

    hybrid 129/Sv × C57BL/6 background

13. Biological process studied

    Response to stress

14. Biological process studied

    memory

15. Genetic Alteration(s)

    Dbh[tm1Rpa]

16. Phenotype Findings

    Corticosterone induced impairment of memory

17. Location

    Steven Thomas Laboratory