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CRF2−/−

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000141-27d2-ff7e-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "CRF2−/− mice were generated in-house on a mixed C57BL/6:129J background as described." A targeting vector was constructed "in which the portion of Crhr2 encoding one-half of the fifth transmembrane domain through the end of the seventh transmembrane domain was replaced with a neomycin-resistant gene cassette". Targeted ES cells were injected into C57BL/6 blastocysts to generate chimaeric mice.
  2. Additional Name
    Crhr2-null mice
  3. Related Publication or Documentation
    Antiinflammatory Treatment Ameliorates HPA Stress Axis Dysfunction in a Mouse Model of Stress Sensitivity
  4. Website(s)
    http://www.informatics.jax.org/allele/MGI:2178545
  5. Parental Strain Name
    C57BL/6:129J
  6. Biological process studied
    Response to stress
  7. Genetic Alteration(s)
    Crhr2[tm1Klee]
  8. Phenotype Findings
    Increased Anxiety-Related Response
  9. Phenotype Findings
    Abnormal Systemic Arterial Blood Pressure
  10. Location
    Bale Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-09-16T13:49:36.811-04:00
  4. creator
    laavanya (Laavanya Sankaranarayanan)
  5. modified
    2016-06-29T16:53:07.803-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016