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CREB(alpha delta)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000141-3c15-aee2-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "A promoterless neomycin resistance gene was inserted in frame into exon 2. RNase protection assays on RNA derived from liver of homozyogous mice demonstrated that no detectable alpha or delta isoform transcript was produced from this allele; however, a beta isoform transcript is upregulated. Western blot analysis on liver extracts from homozygous mice confirmed that no alpha or delta isoform of the encoded protein was produced."
  2. Additional Name
    CREB-deficient mice
  3. Additional Name
    CREBαΔ
  4. Related Disease
    substance-related disorder
  5. Related Publication or Documentation
    cAMP Response Element-Binding Protein Is Required for Stress But Not Cocaine-Induced Reinstatement
  6. Related Publication or Documentation
    cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs.
  7. Related Publication or Documentation
    Regulation of antidepressant activity by cAMP response element binding proteins.
  8. Related Publication or Documentation
    Mu-opioid receptor and CREB activation are required for nicotine reward.
  9. Related Publication or Documentation
    The role of cAMP response element-binding proteins in mediating stress-induced vulnerability to drug abuse.
  10. Related Publication or Documentation
    cAMP response element-binding protein deficiency allows for increased neurogenesis and a rapid onset of antidepressant response.
  11. Related Publication or Documentation
    Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB.
  12. Related Publication or Documentation
    Molecular and genetic substrates linking stress and addiction.
  13. Related Publication or Documentation
    Differential effects of acute and repeated citalopram in mouse models of anxiety and depression.
  14. Related Publication or Documentation
    Increased hippocampal neurogenesis and accelerated response to antidepressants in mice with specific deletion of CREB in the hippocampus: role of cAMP response-element modulator τ.
  15. Related Publication or Documentation
    Ventral tegmental afferents in stress-induced reinstatement: the role of cAMP response element-binding protein.
  16. Related Publication or Documentation
    Differential distribution of CREB in the mesolimbic dopamine reward pathway.
  17. Related Publication or Documentation
    Not all stress is equal: CREB is not necessary for restraint stress reinstatement of cocaine-conditioned reward.
  18. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=3853#nomenclature
  19. Biological process studied
    Response to stress
  20. Biological process studied
    Behavior
  21. Biological process studied
    neurological system process
  22. Genetic Alteration(s)
    Creb1[tm1Gsc]
  23. Location
    Julie Blendy Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-09-20T11:56:35.569-04:00
  4. creator
    apernot (Anne Claire Pernot)
  5. modified
    2013-11-11T15:36:40.337-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016