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Adrb1-/-

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000141-5fcd-faa9-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Adrb1-/- KO mice were generated by mating either heterozygotes or homozygotes on a hybrid 129/Sv × C57BL/6 background, and the genotype was determined by PCR. These mice exhibit targeted disruption of the gene for the β1 receptor. "Mice that are homozygous null for the Adrb1 and Adrb2 genes are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Stimulation of beta adrenergic receptor function in these mice by agonists or exercise reveals significant impairments in chronotropic range, vascular reactivity and metabolic rate. A severely attenuated chronotropic and hypotensive response is observed after administration of the non-selective beta adrenergic receptor agonist isoproterenol. An abnormal response to epinephrine is also seen, with bradycardia and a monophasic hypertensive blood pressure change being observed rather than the tachycardia and biphasic hypertensive/ hypotensive response seen in wildtype mice. When exercised, heart rates in null mice are lower than that of wild type mice. No difference is noted in the resting heart rate." "We thank Brian Kobilka (Stanford University, CA) for providing stock for the β receptor KO mouse lines."
  2. Additional Name
    β1AR KO
  3. Related Publication or Documentation
    Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling.
  4. Related Publication or Documentation
    Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
  5. Related Publication or Documentation
    The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.
  6. Related Publication or Documentation
    Redundant catecholamine signaling consolidates fear memory via phospholipase C.
  7. Website(s)
    http://jaxmice.jax.org/strain/003810.html
  8. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=1293
  9. Parental Strain Name
    hybrid 129/Sv × C57BL/6 background
  10. Biological process studied
    memory
  11. Genetic Alteration(s)
    Adrb1[tm1Bkk]
  12. Phenotype Findings
    Impaired contextual memory retrieval
  13. Location
    Steven Thomas Laboratory
 
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016