Adrb2-/-

eagle-i ID

Resource Type

Properties

1. Resource Description

   β2 KO mice have targeted disruption of the gene for β2-adrenergic receptor and were generated by mating either heterozygotes or homozygotes. "Mice that are homozygous null for the Adrb1 and Adrb2 genes are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Stimulation of beta adrenergic receptor function in these mice by agonists or exercise reveals significant impairments in chronotropic range, vascular reactivity and metabolic rate. A severely attenuated chronotropic and hypotensive response is observed after administration of the non-selective beta adrenergic receptor agonist isoproterenol. An abnormal response to epinephrine is also seen, with bradycardia and a monophasic hypertensive blood pressure change being observed rather than the tachycardia and biphasic hypertensive/ hypotensive response seen in wildtype mice. When exercised, heart rates in null mice are lower than that of wild type mice. No difference is noted in the resting heart rate." "We thank Brian Kobilka (Stanford University, CA) for providing stock for the β receptor KO mouse lines."

2. Additional Name

   β2AR KO

3. Related Publication or Documentation

   Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling.

4. Related Publication or Documentation

   Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.

5. Related Publication or Documentation

   Redundant catecholamine signaling consolidates fear memory via phospholipase C.

6. Website(s)

   http://jaxmice.jax.org/strain/003810.html

7. Website(s)

   http://www.informatics.jax.org/allele/key/2409

8. Parental Strain Name

   hybrid 129/Sv × C57BL/6 background

9. Biological process studied

   memory

10. Genetic Alteration(s)

    Adrb2[tm1Bkk]

11. Location

    Steven Thomas Laboratory