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ECM-coated acrylamide hydrogels

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Resource Type

  1. Material production service


  1. Fee for service
  2. Resource Description
    "<b>ECM-coated acrylamide hydrogels</b> represent a recent advance in cell culture that allows investigators to model the elastic microenvironments that most cell types inhabit in vivo. A growing literature indicates that cellular responses are strongly influenced by the stiffness of the underlying substratum. By culturing cells on ECM-coated hydrogels, investigators can minimize the chance of obtaining the false-negative and false-positive results that may occur when cells are cultured on biologically irrelevant plastic or glass surfaces. Cells cultured on hydrogel substrata are amenable to almost all modern cell and molecular analyses. Continuous cell lines and primary cells are readily accommodated. The elasticity of these substrata can be varied to model changes in microenvironment stiffness that might occur with development, differentiation, or disease."
  3. Topic
    Cellular response to stimulus
  4. Service Provided by
    Biomechanics Core Facility (Penn)
  5. Website(s)
  6. Related Technique
    Cell culturing
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016