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ECM-coated acrylamide hydrogels

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000141-986d-3b62-91c7-0c6080000000

Resource Type

  1. Material production service

Properties

  1. Fee for service
    No
  2. Resource Description
    "<b>ECM-coated acrylamide hydrogels</b> represent a recent advance in cell culture that allows investigators to model the elastic microenvironments that most cell types inhabit in vivo. A growing literature indicates that cellular responses are strongly influenced by the stiffness of the underlying substratum. By culturing cells on ECM-coated hydrogels, investigators can minimize the chance of obtaining the false-negative and false-positive results that may occur when cells are cultured on biologically irrelevant plastic or glass surfaces. Cells cultured on hydrogel substrata are amenable to almost all modern cell and molecular analyses. Continuous cell lines and primary cells are readily accommodated. The elasticity of these substrata can be varied to model changes in microenvironment stiffness that might occur with development, differentiation, or disease."
  3. Topic
    Cellular response to stimulus
  4. Service Provided by
    Biomechanics Core Facility (Penn)
  5. Website(s)
    http://www.itmat.upenn.edu/BiomechanicsCoreFacility.shtml
  6. Related Technique
    Cell culturing
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-10-08T10:17:38.733-04:00
  4. creator
    fcoldren
  5. modified
    2016-05-17T13:08:44.134-04:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016