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Atomic force microscopy

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000141-987b-1f04-91c7-0c6080000000

Resource Type

  1. Material analysis service

Properties

  1. Resource Description
    "<b>Atomic Force Microscopy (AFM)</b> is a technique the Core offers to measure cell or tissue stiffness. Increased tissues stiffness is a hallmarks of fibrosis-associated diseases, and recent data suggests that increased stiffness can be causal for disease progression. AFM performed on freshly isolated tissues can be used to determine how various stimuli or disease affects microenvironmental stiffness. Additionally, this information can then be applied to the generation of hydrogels. In this manner, in vitro mechanistic analyses can be performed under conditions that model the known elasticity of in vivo experimental systems. AFM performed on live cells can be used to monitor changes in intracellular stiffness most commonly associated with regulators of Rho GTPases."
  2. Topic
    endomyocardial fibrosis
  3. Topic
    pulmonary fibrosis
  4. Topic
    Crohn's disease
  5. Service Provided by
    Biomechanics Core Facility (Penn)
  6. Website(s)
    http://www.itmat.upenn.edu/BiomechanicsCoreFacility.shtml
  7. Related Technique
    Atomic force microscopy
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-10-08T10:42:26.713-04:00
  4. creator
    fcoldren
  5. modified
    2016-05-17T13:21:04.808-04:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016