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Atomic force microscopy

eagle-i ID


Resource Type

  1. Material analysis service


  1. Resource Description
    "<b>Atomic Force Microscopy (AFM)</b> is a technique the Core offers to measure cell or tissue stiffness. Increased tissues stiffness is a hallmarks of fibrosis-associated diseases, and recent data suggests that increased stiffness can be causal for disease progression. AFM performed on freshly isolated tissues can be used to determine how various stimuli or disease affects microenvironmental stiffness. Additionally, this information can then be applied to the generation of hydrogels. In this manner, in vitro mechanistic analyses can be performed under conditions that model the known elasticity of in vivo experimental systems. AFM performed on live cells can be used to monitor changes in intracellular stiffness most commonly associated with regulators of Rho GTPases."
  2. Topic
    endomyocardial fibrosis
  3. Topic
    pulmonary fibrosis
  4. Topic
    Crohn's disease
  5. Service Provided by
    Biomechanics Core Facility (Penn)
  6. Website(s)
  7. Related Technique
    Atomic force microscopy
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016