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Adrb3-/-

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000141-a295-59cd-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    β3 KO mice have targeted disruption of the gene for β3-adrenergic receptor were "generated by mating either heterozygotes or homozygotes, and genotype was determined by PCR." The targeted disruption was generated in the following manner: "A 306bp genomic fragment containing the sequences encoding the third through the fifth transmembrane domains was replaced with a neomycin selection cassette." "We thank [...] B. Lowell for providing stock for the β receptor KO mouse lines."
  2. Additional Name
    β3 KO
  3. Related Publication or Documentation
    Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
  4. Website(s)
    http://www.informatics.jax.org/allele/key/2471
  5. Parental Strain Name
    hybrid FVB/N × 129/Sv × C57BL/6 × DBA/2 background
  6. Biological process studied
    memory
  7. Genetic Alteration(s)
    Adrb3[tm1Lowl]
  8. Location
    Steven Thomas Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-10-10T10:05:56.246-04:00
  4. creator
    apernot (Anne Claire Pernot)
  5. modified
    2013-10-29T10:57:01.217-04:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016