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beta1/beta3 double KO
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000141-e19f-e8f4-91c7-0c6080000000
Resource Type
Properties
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Resource Description
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These mice have targeted disruption of the gene for β1- and β3-adrenergic receptors and were generated by crossing β1 KO mice with β3 KO mice.
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Additional Name
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beta1,3-less mice
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Additional Name
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β1/β3 AR DKO
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Related Publication or Documentation
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Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.
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Parental Strain Name
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hybrid FVB/N × 129/Sv × C57BL/6 × DBA/2 background
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Biological process studied
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memory
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Genetic Alteration(s)
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Adrb1[tm1Bkk]
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Genetic Alteration(s)
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Adrb3[tm1Lowl]
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Phenotype Findings
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Brown adipose tissue phenotype
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Location
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Steven Thomas Laboratory
The University of Pennsylvania
