beta1/beta2/beta3 triple KO

eagle-i ID

Resource Type

Properties

1. Resource Description

   These mice have targeted disruption of the gene for β1-, β2-, and β3-adrenergic receptors. "We thank [...] B. Kobilka and B. Lowell for providing stock for the β receptor KO mouse lines."

2. Additional Name

   beta-less mice

3. Related Publication or Documentation

   Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.

4. Parental Strain Name

   hybrid FVB/N × 129/Sv × C57BL/6 × DBA/2 background

5. Biological process studied

   memory

6. Genetic Alteration(s)

   Adrb1[tm1Bkk]

7. Genetic Alteration(s)

   Adrb2[tm1Bkk]

8. Genetic Alteration(s)

   Adrb3[tm1Lowl]

9. Location

   Steven Thomas Laboratory