Drd1-/-

eagle-i ID

Resource Type

Properties

1. Resource Description

   This line was first described by Xu et al. in "Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses" (PMID: 7954836). D1 KO mice have targeted disruption of the gene for dopamine receptor D1A and were "generated by mating either heterozygotes or homozygotes, and genotype was determined by PCR." "We thank [...] M. Xu (University of Chicago) [...] for providing stock for the [...] DA receptor KO mouse lines."

2. Additional Name

   D1 KO

3. Related Publication or Documentation

   Redundant catecholamine signaling consolidates fear memory via phospholipase C.

4. Website(s)

   http://www.informatics.jax.org/allele/key/6109

5. Parental Strain Name

   hybrid 129/Sv × C57BL/6 background

6. Biological process studied

   memory

7. Genetic Alteration(s)

   Drd1[atm1Stl]

8. Location

   Steven Thomas Laboratory