See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.
Drd1-/-
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000141-efc4-a04c-91c7-0c6080000000
Resource Type
Properties
-
-
Resource Description
-
This line was first described by Xu et al. in "Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses" (PMID: 7954836).
D1 KO mice have targeted disruption of the gene for dopamine receptor D1A and were "generated by mating either heterozygotes or homozygotes, and genotype was determined by PCR."
"We thank [...] M. Xu (University of Chicago) [...] for providing stock for the [...] DA receptor KO mouse lines."
-
-
Additional Name
-
D1 KO
-
-
Related Publication or Documentation
-
Redundant catecholamine signaling consolidates fear memory via phospholipase C.
-
-
Website(s)
-
http://www.informatics.jax.org/allele/key/6109
-
-
Parental Strain Name
-
hybrid 129/Sv × C57BL/6 background
-
-
Biological process studied
-
memory
-
-
Genetic Alteration(s)
-
Drd1[atm1Stl]
-
-
Location
-
Steven Thomas Laboratory
