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Chrm1−/−

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000141-efe8-200d-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Homozygotes are viable and fertile with complete absence of the wildtype allele mRNA in forebrain tissues. Mice homozygous for this M1 muscarinic acetylcholine receptor deficiency have elevated dopaminergic transmission in the striatum, significantly increased locomotor activity, increased response to the stimulatory effects of amphetamine. These mutant mice may be useful in neurological studies, including the regulation of dopaminergic transmission by the M1 receptor and M1 dysfunction in psychiatric disorders."
  2. Additional Name
    M1MR KO
  3. Related Disease
    myopia
  4. Website(s)
    http://jaxmice.jax.org/strain/006468.html
  5. Biological process studied
    neurological system process
  6. Genetic Alteration(s)
    Chrm1[tm1Stl]
  7. Location
    Steven Thomas Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-10-25T10:08:40.479-04:00
  4. creator
    apernot (Anne Claire Pernot)
  5. modified
    2013-11-08T10:57:57.400-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016