Grm5−/−

eagle-i ID

Resource Type

Properties

1. Resource Description

   "Mice homozygous for the targeted mutation are viable and fertile. Long-term potentiation (LTP) in homozygous mutant mice is significantly reduced in the NMDA receptor (NMDAR)-dependent pathways such as the CA1 region and dentate gyrus of the hippocampus, whereas LTP remains intact in the mossy fiber synapses on the CA3 region, an NMDAR-independent pathway. These mutant mice also show impairments in the acquisition and use of spatial information in both the Morris water maze and contextual information in the fear-conditioning test."

2. Additional Name

   GluM5 KO

3. Website(s)

   http://jaxmice.jax.org/strain/003121.html

4. Biological process studied

   Behavior

5. Biological process studied

   neurological system process

6. Genetic Alteration(s)

   Grm5[tm1Rod]

7. Location

   Steven Thomas Laboratory