eagle-i The University of PennsylvaniaThe University of Pennsylvania
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Grm5−/−

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000142-1a22-0688-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Mice homozygous for the targeted mutation are viable and fertile. Long-term potentiation (LTP) in homozygous mutant mice is significantly reduced in the NMDA receptor (NMDAR)-dependent pathways such as the CA1 region and dentate gyrus of the hippocampus, whereas LTP remains intact in the mossy fiber synapses on the CA3 region, an NMDAR-independent pathway. These mutant mice also show impairments in the acquisition and use of spatial information in both the Morris water maze and contextual information in the fear-conditioning test."
  2. Additional Name
    GluM5 KO
  3. Website(s)
    http://jaxmice.jax.org/strain/003121.html
  4. Biological process studied
    Behavior
  5. Biological process studied
    neurological system process
  6. Genetic Alteration(s)
    Grm5[tm1Rod]
  7. Location
    Steven Thomas Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-11-02T14:49:00.633-04:00
  4. creator
    apernot (Anne Claire Pernot)
  5. modified
    2013-11-08T11:01:51.524-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016