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Grm5−/−
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000142-1a22-0688-91c7-0c6080000000
Resource Type
Properties
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Resource Description
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"Mice homozygous for the targeted mutation are viable and fertile. Long-term potentiation (LTP) in homozygous mutant mice is significantly reduced in the NMDA receptor (NMDAR)-dependent pathways such as the CA1 region and dentate gyrus of the hippocampus, whereas LTP remains intact in the mossy fiber synapses on the CA3 region, an NMDAR-independent pathway. These mutant mice also show impairments in the acquisition and use of spatial information in both the Morris water maze and contextual information in the fear-conditioning test."
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Additional Name
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GluM5 KO
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Website(s)
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http://jaxmice.jax.org/strain/003121.html
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Biological process studied
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Behavior
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Biological process studied
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neurological system process
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Genetic Alteration(s)
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Grm5[tm1Rod]
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Location
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Steven Thomas Laboratory
