Nestin-Cre Tg

eagle-i ID

Resource Type

Properties

1. Resource Description

   "These transgenic mice express Cre recombinase under the control of the rat nestin promoter and enhancer. Mice that are hemizygous for the transgenic insert are viable and fertile. Initial studies utilizing a reporter strain carrying a beta galactosidase transgene whose expression is dependent on Cre-mediated recombination indicate that cre is primarily expressed in the central and peripheral nervous system with a few isolated kidney and heart cells also expressing activity. The donating investigator indicates that Cre recombinase activity is present in nervous tissue by embryonic day 11. The transgene insertion location is on Chromosome 12, as determined by FISH analysis, view pdf." PDF is available from link below.

2. Website(s)

   http://jaxmice.jax.org/strain/003771.html

3. Biological process studied

   neurological system process

4. Genetic Alteration(s)

   Tg(Nes-cre)1Kln

5. Location

   Steven Thomas Laboratory