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POMC-Cre Tg

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000142-1a67-78af-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "In this strain, the mouse pro-opiomelanocortin-alpha (Pomc) promoter drives expression of cre in the central nervous system, primarily the hippocampus. Cre expression is strongest and most restricted to the granule cells of the dentate gyrus subregion. Weaker, scattered expression can also be detected in other regions including the arcuate nucleus of the hypothalamus and the habenular nucleus. When crossed with a strain carrying a loxP-flanked genomic segment of interest, tissue-specific excision of that segment may be achieved. In POMC-cre and loxP-flanked (floxed) strain intercrosses, using male cre animals is recommended. According to the donating investigator, passing the cre through the female germline can result in a high percentage of offspring that carry the recombined allele in all of their tissues. Such "leaky" Cre expression is reported in male POMC-cre mice also, but at a lower frequency (< 5%). The frequency of "leaky" expression in male POMC-cre mice, however, increases with the animal's age."
  2. Website(s)
    http://jaxmice.jax.org/strain/010714.html
  3. Biological process studied
    neurological system process
  4. Genetic Alteration(s)
    Tg(Pomc-cre)1Stl
  5. Location
    Steven Thomas Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-11-02T16:01:49.469-04:00
  4. creator
    apernot (Anne Claire Pernot)
  5. modified
    2013-11-08T11:16:30.162-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016