POMC-Cre Tg

eagle-i ID

Resource Type

Properties

1. Resource Description

   "In this strain, the mouse pro-opiomelanocortin-alpha (Pomc) promoter drives expression of cre in the central nervous system, primarily the hippocampus. Cre expression is strongest and most restricted to the granule cells of the dentate gyrus subregion. Weaker, scattered expression can also be detected in other regions including the arcuate nucleus of the hypothalamus and the habenular nucleus. When crossed with a strain carrying a loxP-flanked genomic segment of interest, tissue-specific excision of that segment may be achieved. In POMC-cre and loxP-flanked (floxed) strain intercrosses, using male cre animals is recommended. According to the donating investigator, passing the cre through the female germline can result in a high percentage of offspring that carry the recombined allele in all of their tissues. Such "leaky" Cre expression is reported in male POMC-cre mice also, but at a lower frequency (< 5%). The frequency of "leaky" expression in male POMC-cre mice, however, increases with the animal's age."

2. Website(s)

   http://jaxmice.jax.org/strain/010714.html

3. Biological process studied

   neurological system process

4. Genetic Alteration(s)

   Tg(Pomc-cre)1Stl

5. Location

   Steven Thomas Laboratory