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ColX-Tg

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000142-2416-979e-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Transgene constructs encoded chicken collagen X variants with in-frame deletions of either 21 (21Δ, eg, SpLX) or 293 (293Δ, eg, SpLXH) amino acids within the central triple-helical domain. Expression of the chick collagen X 21Δ or 293Δ transgenes in mice was driven by either a 4.7-kb (∼4750 bp upstream from transcription start) or a 1.6-kb (∼1650 bp upstream from transcription start) chicken collagen X promoter fragment. Congenic Lines: Congenic lines were generated by inbreeding each line greater than 12 generations into the C57BL/6 mouse strain. They are labelled 1.6-293Δ -B6 and 4.7-21Δ-B6.
  2. Related Disease
    immune system disease
  3. Related Publication or Documentation
    Defective endochondral ossification-derived matrix and bone cells alter the lymphopoietic niche in collagen X mouse models.
  4. Related Publication or Documentation
    Congenic mice confirm that collagen X is required for proper hematopoietic development.
  5. Related Publication or Documentation
    Altered endochondral ossification in collagen X mouse models leads to impaired immune responses.
  6. Related Publication or Documentation
    Chicken collagen X regulatory sequences restrict transgene expression to hypertrophic cartilage in mice.
  7. Related Publication or Documentation
    Growth plate compressions and altered hematopoiesis in collagen X null mice.
  8. Related Publication or Documentation
    Altered matrix at the chondro-osseous junction leads to defects in lymphopoiesis
  9. Website(s)
    http://www.informatics.jax.org/searches/allele_report.cgi?_Refs_key=159791
  10. Parental Strain Name
    C57BL/6
  11. Biological process studied
    Immune system process
  12. Genetic Alteration(s)
    ColX-Tg
  13. Phenotype Findings
    Chondreo-osseous junction variation
  14. Location
    Olena Jacenko Laboratory
 
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Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016