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B6;129S2-Scarb1tm1Kri/J

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000142-5c9f-e800-91c7-0c6080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The class B, type I scavenger receptor (Srb1 or Scarb1) is a cell surface HDL receptor that can recognize the apolipoproteins on the surface of the HDL particle. It plays a key role in determining the levels of plasma lipoprotein cholesterol (primarily HDL) and the accumulation of cholesterol stores in the adrenal gland.In this strain plasma cholesterol (primarily HDL) concentrations increase by 125% in homozygotes and 31% in heterozygotes, as compared to wild type controls. Also, cholesterol levels in adrenal tissue in homozygous and heterozygous mutants decrease by 72% and 42% respectively, relative to wild type controls. The plasma concentration of Apoa-I, the major protein in HDL, is unchanged in mutant animals, relative to wild type controls.Homozygous females are infertile; homozygous males are fertile. Please note that the donating investigator reports that the number of homozygotes resulting from a cross between heterozygotes is significantly lower than what the expected Mendelian ratio would predict."
  2. Additional Name
    SR-BI KO
  3. Related Disease
    familial hypercholesterolemia
  4. Related Publication or Documentation
    Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport.
  5. Related Publication or Documentation
    PPARγ activation redirects macrophage cholesterol from fecal excretion to adipose tissue uptake in mice via SR-BI.
  6. Related Publication or Documentation
    Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages.
  7. Related Publication or Documentation
    Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.
  8. Related Publication or Documentation
    Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo.
  9. Related Publication or Documentation
    Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo.
  10. Website(s)
    http://jaxmice.jax.org/strain/003379.html
  11. Biological process studied
    Lipid metabolic process
  12. Biological process studied
    Reproductive process
  13. Genetic Alteration(s)
    Scarb1[tm1Kri]
  14. Location
    Rader Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016