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Luning Prak Laboratory

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000142-5d35-dcd9-91c7-0c6080000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    "B cells produce antibodies and are important for innate and adaptive immunity. B cells that are improperly regulated can also cause or contribute to autoimmunity. Our major research interest is in defining B cell tolerance checkpoint defects in mouse models and patients with autoimmune diseases. B cells with a functional antibody can undergo further rearrangement, a process termed receptor editing. Receptor editing is a significant mechanism for central (early) B cell tolerance. Recent work from our lab demonstrates lower levels of editing in approximately 30% of patients with lupus and 30% of patients with type 1 diabetes, as well as in mouse models of these diseases. These findings suggest that a significant proportion of patients with different autoimmune diseases have defects in early B cell tolerance, and may provide insights into which patients will respond best to B cell targeted therapy."
  2. Contact
    Tsao, Patricia., MD, PhD
  3. PI
    Luning Prak, Eline., MD, PhD
  4. Affiliation
    Department of Pathology and Laboratory Medicine, University of Pennsylvania
  5. Website(s)
    http://www.med.upenn.edu/apps/faculty/index.php/g5455356/p13338
  6. Secondary affiliation
    Penn Institute for Immunology
 
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Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016