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B6.56R
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000142-c847-f240-56aa-39e480000000
Resource Type
Properties
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Resource Description
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Anti-dsDNA antibody heavy chain knock-in mouse bred on B6 background.
The heterozygous B6.56R mouse has an in-frame 56R H chain rearrangement inserted in the JH locus on one allele (the 56R allele).
The B6.56R model has three important properties that can be exploited to study H chain rearrangement. First, the H chain is well characterized and is known to produce anti-dsDNA antibodies with all but a handful of L chains. Second, there is a clear precursor-product relationship because all B cells start out with the rearranged 56R H chain DNA. Third, additional H chain rearrangements can be detected phenotypically and genetically.
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Additional Name
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anti-DNA heavy chain knock-in mouse
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Related Publication or Documentation
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Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement.
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Related Publication or Documentation
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Development and selection of edited B cells in B6.56R mice.
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Related Publication or Documentation
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B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren's syndrome.
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Related Publication or Documentation
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RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes.
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Website(s)
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http://www.informatics.jax.org/allele/key/55863
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Parental Strain Name
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C57Bl/6
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Biological process studied
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Immune system process
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Biological process studied
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immunoglobulin production
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Genetic Alteration(s)
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Igh-J[tm2(3H9-VDJ*)Mwg]
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Phenotype Findings
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Spontaneous production of anti-dsDNA antibodies with age.
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Location
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Luning Prak Laboratory
