B6.56R

eagle-i ID

Resource Type

Properties

1. Resource Description

   Anti-dsDNA antibody heavy chain knock-in mouse bred on B6 background. The heterozygous B6.56R mouse has an in-frame 56R H chain rearrangement inserted in the JH locus on one allele (the 56R allele). The B6.56R model has three important properties that can be exploited to study H chain rearrangement. First, the H chain is well characterized and is known to produce anti-dsDNA antibodies with all but a handful of L chains. Second, there is a clear precursor-product relationship because all B cells start out with the rearranged 56R H chain DNA. Third, additional H chain rearrangements can be detected phenotypically and genetically.

2. Additional Name

   anti-DNA heavy chain knock-in mouse

3. Related Publication or Documentation

   Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement.

4. Related Publication or Documentation

   Development and selection of edited B cells in B6.56R mice.

5. Related Publication or Documentation

   B-cell tolerance defects in the B6.Aec1/2 mouse model of Sjögren's syndrome.

6. Related Publication or Documentation

   RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes.

7. Website(s)

   http://www.informatics.jax.org/allele/key/55863

8. Parental Strain Name

   C57Bl/6

9. Biological process studied

   Immune system process

10. Biological process studied

    immunoglobulin production

11. Genetic Alteration(s)

    Igh-J[tm2(3H9-VDJ*)Mwg]

12. Phenotype Findings

    Spontaneous production of anti-dsDNA antibodies with age.

13. Location

    Luning Prak Laboratory