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Oprm1 A112G
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000142-fc45-3d75-55c9-beb080000000
Resource Type
Properties
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Resource Description
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"The construction of the A112G allele was accomplished by using a bacterial artificial chromosome (BAC) containing the entire Oprm1 locus derived from C57BL/6 mouse DNA. The region containing exon 1 and flanking introns was used as the template for site-directed mutagenesis.
The polymorphism in exon 1 was constructed by changing the
adenosine (A) nucleotide at position 112 of the mouse, which
corresponds to position 118 in the human sequence, to a
guanosine (G). A second mutation (T108C) was introduced."
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Additional Name
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Oprm1 tm1Jabl
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Related Disease
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pain disorder
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Related Disease
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substance-related disorder
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Related Publication or Documentation
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Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior
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Website(s)
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http://www.informatics.jax.org/reference/MGI:3851884
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Parental Strain Name
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C57BL/6
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Genetic Alteration(s)
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Oprm1[tm1Jabl]
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Phenotype Findings
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Pain sensitivity
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Location
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Julie Blendy Laboratory
