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Oprm1 A112G

eagle-i ID


Resource Type

  1. Mus musculus


  1. Resource Description
    "The construction of the A112G allele was accomplished by using a bacterial artificial chromosome (BAC) containing the entire Oprm1 locus derived from C57BL/6 mouse DNA. The region containing exon 1 and flanking introns was used as the template for site-directed mutagenesis. The polymorphism in exon 1 was constructed by changing the adenosine (A) nucleotide at position 112 of the mouse, which corresponds to position 118 in the human sequence, to a guanosine (G). A second mutation (T108C) was introduced."
  2. Additional Name
    Oprm1 tm1Jabl
  3. Related Disease
    pain disorder
  4. Related Disease
    substance-related disorder
  5. Related Publication or Documentation
    Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior
  6. Website(s)
  7. Parental Strain Name
  8. Genetic Alteration(s)
  9. Phenotype Findings
    Pain sensitivity
  10. Location
    Julie Blendy Laboratory
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
  3. created
  4. creator
    laavanya (Laavanya Sankaranarayanan)
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016