Oprm1 A112G

eagle-i ID

Resource Type

Properties

1. Resource Description

   "The construction of the A112G allele was accomplished by using a bacterial artificial chromosome (BAC) containing the entire Oprm1 locus derived from C57BL/6 mouse DNA. The region containing exon 1 and flanking introns was used as the template for site-directed mutagenesis. The polymorphism in exon 1 was constructed by changing the adenosine (A) nucleotide at position 112 of the mouse, which corresponds to position 118 in the human sequence, to a guanosine (G). A second mutation (T108C) was introduced."

2. Additional Name

   Oprm1 tm1Jabl

3. Related Disease

   pain disorder

4. Related Disease

   substance-related disorder

5. Related Publication or Documentation

   Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior

6. Website(s)

   http://www.informatics.jax.org/reference/MGI:3851884

7. Parental Strain Name

   C57BL/6

8. Genetic Alteration(s)

   Oprm1[tm1Jabl]

9. Phenotype Findings

   Pain sensitivity

10. Location

    Julie Blendy Laboratory