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Oprm1 A112G

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000142-fc45-3d75-55c9-beb080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The construction of the A112G allele was accomplished by using a bacterial artificial chromosome (BAC) containing the entire Oprm1 locus derived from C57BL/6 mouse DNA. The region containing exon 1 and flanking introns was used as the template for site-directed mutagenesis. The polymorphism in exon 1 was constructed by changing the adenosine (A) nucleotide at position 112 of the mouse, which corresponds to position 118 in the human sequence, to a guanosine (G). A second mutation (T108C) was introduced."
  2. Additional Name
    Oprm1 tm1Jabl
  3. Related Disease
    pain disorder
  4. Related Disease
    substance-related disorder
  5. Related Publication or Documentation
    Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior
  6. Website(s)
    http://www.informatics.jax.org/reference/MGI:3851884
  7. Parental Strain Name
    C57BL/6
  8. Genetic Alteration(s)
    Oprm1[tm1Jabl]
  9. Phenotype Findings
    Pain sensitivity
  10. Location
    Julie Blendy Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2013-12-16T12:11:37.651-05:00
  4. creator
    laavanya (Laavanya Sankaranarayanan)
  5. modified
    2014-01-09T14:10:21.032-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016