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129S-Parp-1tm1Zqw/J

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000143-930b-eee6-55c9-beb080000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Mice that are homozygous for the poly(ADP-ribose) polymerase-1 null mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Although a shortened transcript is generated, no enzymatic activity is detected in tissues. Proliferation of homozygous fibroblasts and thymocytes is impaired following gamma-radiation in comparison to cells derived from wildtype mice. Older mice are susceptible to spontaneous development of skin disease. A significant portion of older mice (~30%) can be expected to exhibit epidermal hyperplasia. Null mice are also less susceptible to damage induced by the neurotoxin MPTP."
  2. Additional Name
    Parp-1 (−/−)
  3. Related Disease
    neurodegenerative disease
  4. Related Disease
    Parkinson's disease
  5. Related Publication or Documentation
    Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes.
  6. Website(s)
    http://jaxmice.jax.org/strain/002779.html
  7. Biological process studied
    Regulation of apoptotic process
  8. Genetic Alteration(s)
    Parp1[tm1Zqw]
  9. Location
    De La Fuente Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016