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129S-Parp-1tm1Zqw/J
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000143-930b-eee6-55c9-beb080000000
Resource Type
Properties
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Resource Description
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"Mice that are homozygous for the poly(ADP-ribose) polymerase-1 null mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Although a shortened transcript is generated, no enzymatic activity is detected in tissues. Proliferation of homozygous fibroblasts and thymocytes is impaired following gamma-radiation in comparison to cells derived from wildtype mice. Older mice are susceptible to spontaneous development of skin disease. A significant portion of older mice (~30%) can be expected to exhibit epidermal hyperplasia. Null mice are also less susceptible to damage induced by the neurotoxin MPTP."
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Additional Name
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Parp-1 (−/−)
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Related Disease
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neurodegenerative disease
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Related Disease
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Parkinson's disease
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Related Publication or Documentation
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Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes.
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Website(s)
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http://jaxmice.jax.org/strain/002779.html
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Biological process studied
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Regulation of apoptotic process
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Genetic Alteration(s)
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Parp1[tm1Zqw]
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Location
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De La Fuente Laboratory
