129S-Parp-1tm1Zqw/J

eagle-i ID

Resource Type

Properties

1. Resource Description

   "Mice that are homozygous for the poly(ADP-ribose) polymerase-1 null mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Although a shortened transcript is generated, no enzymatic activity is detected in tissues. Proliferation of homozygous fibroblasts and thymocytes is impaired following gamma-radiation in comparison to cells derived from wildtype mice. Older mice are susceptible to spontaneous development of skin disease. A significant portion of older mice (~30%) can be expected to exhibit epidermal hyperplasia. Null mice are also less susceptible to damage induced by the neurotoxin MPTP."

2. Additional Name

   Parp-1 (−/−)

3. Related Disease

   neurodegenerative disease

4. Related Disease

   Parkinson's disease

5. Related Publication or Documentation

   Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes.

6. Website(s)

   http://jaxmice.jax.org/strain/002779.html

7. Biological process studied

   Regulation of apoptotic process

8. Genetic Alteration(s)

   Parp1[tm1Zqw]

9. Location

   De La Fuente Laboratory