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SLP76-KO

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000144-c1d1-e6e3-3e6a-4e4480000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "About 360 base pairs (bp) of the SLP-76 genomic locus, including 145 bp of the first exon containing the translational start site, were replaced with a neomycin resistance cassette in the reverse transcriptional orientation. Two of the clones were microinjected into C57BL/6 blastocysts, and chimeric mice were then bred to wild-type C57BL/6 mice. Heterozygous mice were then mated to obtain homozygous SLP-76–deficient mice."
  2. Additional Name
    SLP-76–deficient mice
  3. Related Publication or Documentation
    Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production
  4. Related Publication or Documentation
    Understanding signal integration through targeted mutations of an adapter protein
  5. Related Publication or Documentation
    Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation
  6. Related Publication or Documentation
    Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
  7. Related Publication or Documentation
    SLP-76 regulates Fcgamma receptor and integrin signaling in neutrophils
  8. Parental Strain Name
    C57BL/6
  9. Biological process studied
    Immune system process
  10. Genetic Alteration(s)
    Lcp2[tm1Gak]
  11. Phenotype Findings
    Lack of peripheral T cells
  12. Location
    Koretzky Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2014-03-14T14:44:50.224-04:00
  4. creator
    laavanya (Laavanya Sankaranarayanan)
  5. modified
    2014-04-08T13:14:11.366-04:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016