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Y145F

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000144-c2a5-3d7a-3e6a-4e4480000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    Mice were generated expressing SLP76 containing a single mutation in Y145 to phenylalanine (Y145F mice).
  2. Related Disease
    vascular disease
  3. Related Publication or Documentation
    Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo
  4. Related Publication or Documentation
    Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76
  5. Website(s)
    http://www.informatics.jax.org/allele/key/57394
  6. Parental Strain Name
    C57BL/6
  7. Biological process studied
    Immune system process
  8. Genetic Alteration(s)
    Lcp2[tm3Gak]
  9. Phenotype Findings
    Abnormal negative Tcell selection
  10. Location
    Koretzky Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2014-03-14T18:18:56.025-04:00
  4. creator
    laavanya (Laavanya Sankaranarayanan)
  5. modified
    2014-04-08T13:29:37.219-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016