Y145F

eagle-i ID

Resource Type

Properties

1. Resource Description

   Mice were generated expressing SLP76 containing a single mutation in Y145 to phenylalanine (Y145F mice).

2. Related Disease

   vascular disease

3. Related Publication or Documentation

   Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo

4. Related Publication or Documentation

   Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76

5. Website(s)

   http://www.informatics.jax.org/allele/key/57394

6. Parental Strain Name

   C57BL/6

7. Biological process studied

   Immune system process

8. Genetic Alteration(s)

   Lcp2[tm3Gak]

9. Phenotype Findings

   Abnormal negative Tcell selection

10. Location

    Koretzky Laboratory