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SLP-76+/−
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000144-d0bf-9108-3e6a-4e4480000000
Resource Type
Properties
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Resource Description
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"About 360 base pairs (bp) of the SLP-76 genomic locus, including 145 bp of the first exon containing the translational start site, were replaced with a neomycin resistance cassette in the reverse transcriptional orientation.
Two of the clones were microinjected into C57BL/6 blastocysts, and chimeric mice were then bred to wild-type C57BL/6 mice. "
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Related Publication or Documentation
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Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
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Related Publication or Documentation
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Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
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Website(s)
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http://www.informatics.jax.org/allele/key/6836
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Parental Strain Name
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C57BL/6
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Biological process studied
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Immune system process
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Genetic Alteration(s)
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Lcp2[tm1Gak]
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Location
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Koretzky Laboratory
