SLP-76+/−

eagle-i ID

Resource Type

Properties

1. Resource Description

   "About 360 base pairs (bp) of the SLP-76 genomic locus, including 145 bp of the first exon containing the translational start site, were replaced with a neomycin resistance cassette in the reverse transcriptional orientation. Two of the clones were microinjected into C57BL/6 blastocysts, and chimeric mice were then bred to wild-type C57BL/6 mice. "

2. Related Publication or Documentation

   Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development

3. Related Publication or Documentation

   Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors

4. Website(s)

   http://www.informatics.jax.org/allele/key/6836

5. Parental Strain Name

   C57BL/6

6. Biological process studied

   Immune system process

7. Genetic Alteration(s)

   Lcp2[tm1Gak]

8. Location

   Koretzky Laboratory