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SLP-76+/−

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000144-d0bf-9108-3e6a-4e4480000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "About 360 base pairs (bp) of the SLP-76 genomic locus, including 145 bp of the first exon containing the translational start site, were replaced with a neomycin resistance cassette in the reverse transcriptional orientation. Two of the clones were microinjected into C57BL/6 blastocysts, and chimeric mice were then bred to wild-type C57BL/6 mice. "
  2. Related Publication or Documentation
    Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development
  3. Related Publication or Documentation
    Macrophage activation and Fcγ receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors
  4. Website(s)
    http://www.informatics.jax.org/allele/key/6836
  5. Parental Strain Name
    C57BL/6
  6. Biological process studied
    Immune system process
  7. Genetic Alteration(s)
    Lcp2[tm1Gak]
  8. Location
    Koretzky Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2014-03-17T12:52:09.959-04:00
  4. creator
    laavanya (Laavanya Sankaranarayanan)
  5. modified
    2014-04-08T13:13:37.836-04:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016