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Kinetic Modeling and Simulation Core (Penn/CHOP)

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Resource Type

  1. Core Laboratory


  1. Resource Description
    "Kinetic Modeling and Simulation ( KMAS ) core will provide crucial infrastructure to the growing translational effort at the partner institutions of the University of Pennsylvania and Children's Hospital of Philadelphia Clinical & Translational Science Award (CTSA). Jeffrey S. Barrett, Ph.D. of CHOP will direct the core. The core will (a) aid in the development of drug assays; (b) promote and assist in the performance of tracer kinetic studies; (c) develop novel approaches to kinetic data analysis; (d) provide pharmacokinetic (PK), PK– pharmacodynamic (PD), and tracer kinetic modeling; and (e) develop educational modules in pharmacokinetics and tracer kinetics to populate the educational initiatives pursued within the CTSA. <b>Mission</b> The Kinetic Modeling and Simulation (KMAS) Core supports members of the Penn/CHOP CTSA through the planning of experimental designs and clinical investigations as well as the quantitative analysis of such investigations via model-based approaches. A variety of methodologies and techniques are utilized in these endeavors including response surface modeling to aid the construction of efficient dose-response experiments in vitro, nonlinear least squares and moment-based noncompartmental analysis for richly sampled PK and PK/PD analyses, nonlinear mixed-effect modeling and nonparametric analysis (nonparametric EM algorithm) for sparsely sampled, population-based, PK and PK/PD designs, Monte Carlo simulation and Markov Chain Monte Carlo (MCMC) simulation for clinical trial simulation. A variety of algorithms are used to support these efforts (NONMEM, SAS, R, NPEM, WinBUGS, WinNonlin, Trial Simulator) as well as home grown algorithms for specific projects (e.g., discrete event simulation)."
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016