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ATRfl

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000145-4725-7150-0e1e-622880000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The Cre-ERT2 mouse line was generated through lentitransgenesis by microinjection of Cre-ERT2-expressing lentivirus into the perivitelline space of one cell zygotes. To recombine the ATRflox allele using the Cre-ERT2 transgenic system, TAM (MP Biomedicals) was solubilized at 20 mg/ml in a mixture of 98% corn oil and 2% ethanol and delivered into mice by intraperitoneal injection or oral gavage treatment "
  2. Related Disease
    leukemia
  3. Related Disease
    fibrosarcoma
  4. Related Publication or Documentation
    Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR
  5. Related Publication or Documentation
    Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
  6. Related Publication or Documentation
    Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
  7. Website(s)
    http://www.informatics.jax.org/allele/key/23252
  8. Parental Strain Name
    129SvEv/C57BL/6 mixed
  9. Genetic Alteration(s)
    Atr[tm2Bal]
  10. Phenotype Findings
    Age related phenotype
  11. Location
    Brown Laboratory
 
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Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016