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ATRfl
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000145-4725-7150-0e1e-622880000000
Resource Type
Properties
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Resource Description
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"The Cre-ERT2 mouse line was generated through lentitransgenesis by microinjection of Cre-ERT2-expressing lentivirus into the perivitelline space of one cell zygotes. To recombine the ATRflox allele using the Cre-ERT2 transgenic system, TAM (MP Biomedicals) was solubilized at 20 mg/ml in a mixture of 98% corn oil and 2% ethanol and delivered into mice by intraperitoneal injection or oral gavage treatment "
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Related Disease
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leukemia
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Related Disease
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fibrosarcoma
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Related Publication or Documentation
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Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR
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Related Publication or Documentation
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Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss
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Related Publication or Documentation
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Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
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Website(s)
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http://www.informatics.jax.org/allele/key/23252
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Parental Strain Name
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129SvEv/C57BL/6 mixed
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Genetic Alteration(s)
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Atr[tm2Bal]
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Phenotype Findings
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Age related phenotype
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Location
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Brown Laboratory
