ATRfl

eagle-i ID

Resource Type

Properties

1. Resource Description

   "The Cre-ERT2 mouse line was generated through lentitransgenesis by microinjection of Cre-ERT2-expressing lentivirus into the perivitelline space of one cell zygotes. To recombine the ATRflox allele using the Cre-ERT2 transgenic system, TAM (MP Biomedicals) was solubilized at 20 mg/ml in a mixture of 98% corn oil and 2% ethanol and delivered into mice by intraperitoneal injection or oral gavage treatment "

2. Related Disease

   leukemia

3. Related Disease

   fibrosarcoma

4. Related Publication or Documentation

   Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

5. Related Publication or Documentation

   Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss

6. Related Publication or Documentation

   Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53

7. Website(s)

   http://www.informatics.jax.org/allele/key/23252

8. Parental Strain Name

   129SvEv/C57BL/6 mixed

9. Genetic Alteration(s)

   Atr[tm2Bal]

10. Phenotype Findings

    Age related phenotype

11. Location

    Brown Laboratory