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Tlr3−/−
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000145-4cb7-a394-0e1e-622880000000
Resource Type
Properties
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Resource Description
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"Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Northern blot analysis detects a truncated gene product (mRNA), which is not functional. Unlike wildtype macrophages, macrophages derived from these animals fail to produce inflammatory cytokines, IFN-alpha or IFN-beta when challenged with poly(I:C), polyinosine-polycytidylic acid, a synthetic dsRNA analog. Splenocytes isolated from homozygotes do not respond to viral dsRNA and have diminished IL-6 production. Mice homozygous for the mutation are resistant to poly(I:C) induced shock and produce lower levels of IL-12. This mutant mouse strain may be useful in studies of the toll-like receptor pathway of innate immune response."
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Additional Name
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Tlr3−/−
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Related Disease
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hypersensitivity reaction type II disease
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Related Publication or Documentation
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The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes.
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Website(s)
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http://jaxmice.jax.org/strain/005217.html
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Website(s)
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http://www.informatics.jax.org/allele/key/22966
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Biological process studied
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Immune system process
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Biological process studied
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Signal transduction
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Genetic Alteration(s)
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Tlr3[tm1Flv]
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Location
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Albelda Laboratory
