Tlr3−/−

eagle-i ID

Resource Type

Properties

1. Resource Description

   "Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Northern blot analysis detects a truncated gene product (mRNA), which is not functional. Unlike wildtype macrophages, macrophages derived from these animals fail to produce inflammatory cytokines, IFN-alpha or IFN-beta when challenged with poly(I:C), polyinosine-polycytidylic acid, a synthetic dsRNA analog. Splenocytes isolated from homozygotes do not respond to viral dsRNA and have diminished IL-6 production. Mice homozygous for the mutation are resistant to poly(I:C) induced shock and produce lower levels of IL-12. This mutant mouse strain may be useful in studies of the toll-like receptor pathway of innate immune response."

2. Additional Name

   Tlr3−/−

3. Related Disease

   hypersensitivity reaction type II disease

4. Related Publication or Documentation

   The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes.

5. Website(s)

   http://jaxmice.jax.org/strain/005217.html

6. Website(s)

   http://www.informatics.jax.org/allele/key/22966

7. Biological process studied

   Immune system process

8. Biological process studied

   Signal transduction

9. Genetic Alteration(s)

   Tlr3[tm1Flv]

10. Location

    Albelda Laboratory