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Tlr3−/−

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000145-4cb7-a394-0e1e-622880000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Northern blot analysis detects a truncated gene product (mRNA), which is not functional. Unlike wildtype macrophages, macrophages derived from these animals fail to produce inflammatory cytokines, IFN-alpha or IFN-beta when challenged with poly(I:C), polyinosine-polycytidylic acid, a synthetic dsRNA analog. Splenocytes isolated from homozygotes do not respond to viral dsRNA and have diminished IL-6 production. Mice homozygous for the mutation are resistant to poly(I:C) induced shock and produce lower levels of IL-12. This mutant mouse strain may be useful in studies of the toll-like receptor pathway of innate immune response."
  2. Additional Name
    Tlr3−/−
  3. Related Disease
    hypersensitivity reaction type II disease
  4. Related Publication or Documentation
    The vascular disrupting agent, DMXAA, directly activates dendritic cells through a MyD88-independent mechanism and generates antitumor cytotoxic T lymphocytes.
  5. Website(s)
    http://jaxmice.jax.org/strain/005217.html
  6. Website(s)
    http://www.informatics.jax.org/allele/key/22966
  7. Biological process studied
    Immune system process
  8. Biological process studied
    Signal transduction
  9. Genetic Alteration(s)
    Tlr3[tm1Flv]
  10. Location
    Albelda Laboratory
 
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Provenance Metadata About This Resource Record
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016