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Kinetic modeling and simulation service

eagle-i ID


Resource Type

  1. Analysis service


  1. Resource Description
    "The Kinetic Modeling and Simulation (KMAS) Core supports members of the Penn/CHOP CTSA through the planning of experimental designs and clinical investigations as well as the quantitative analysis of such investigations via model-based approaches. A variety of methodologies and techniques are utilized in these endeavors including response surface modeling to aid the construction of efficient dose-response experiments in vitro, nonlinear least squares and moment-based noncompartmental analysis for richly sampled PK and PK/PD analyses, nonlinear mixed-effect modeling and nonparametric analysis (nonparametric EM algorithm) for sparsely sampled, population-based, PK and PK/PD designs, Monte Carlo simulation and Markov Chain Monte Carlo (MCMC) simulation for clinical trial simulation. A variety of algorithms are used to support these efforts (NONMEM, SAS, R, NPEM, WinBUGS, WinNonlin, Trial Simulator) as well as home grown algorithms for specific projects (e.g., discrete event simulation)."
  2. Related Resource
    Discrete Event Simulation for Clinical Trial Simulation
  3. Related Resource
  4. Related Resource
    S-PLUS Professional
  5. Related Resource
    WinNonlin Professional
  6. Related Resource
  7. Related Resource
    Trial Simulator
  8. Related Resource
    SAS-based environment for NONMEM run and post-processing
  9. Service Provided by
  10. Website(s)
  11. Related Technique
    Computational modeling technique
  12. Related Technique
    Clinical trial technique
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016