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Resource Type

  1. Software


  1. Resource Description
    "MR_predictor is a free, open-source simulation engine designed to guide the development and interpretation of statistical tests of causality between phenotypes using genetic instruments. MR_predictor provides a framework to model either individual traits or complex scenarios where multiple phenotypes are correlated or dependent on each other. MR_predictor can incorporate the effects of multiple, independent, biallelic loci contributing genotypic variability to one or more simulated phenotypes. The software has a range of options for sample generation, including ascertainment of a user-specified number cases under a disease model. The output files generated by MR_predictor port into commonly-used analysis tools (e.g., PLINK, R), facilitating a range of analyses germane for Mendelian Randomization studies. MR_predictor is currently implemented in PERL. The package is currently designed for the UNIX/Linux operating environment. MR_predictor is a development project by Benjamin F. Voight, Assistant Professor of Pharmacology and Genetics at the University of Pennsylvania – Perelman School of Medicine."
  2. Used by
    Voight Laboratory
  3. Operating System
  4. Data Input
    genetic information file
  5. Data Input
    phenotypic trait listing file
  6. Data Input
    intermediate trait relationships summary file
  7. Data Input
    intermediate trait to endpoint trait relationships summary file
  8. Data Input
    genetic to trait relationship score file
  9. Data Input
    haplotype information file to simulate linkage disequilibrium
  10. Data Output
    Pedigree file
  11. Data Output
    Map file
  12. Data Output
    Phenotype file
  13. Data Output
    Score file
  14. Data Output
    Covariates file
  15. Data Output
    LD summary files
  16. Software purpose
    Population modeling objective
  17. Related Publication or Documentation
    MR_predictor: a simulation engine for Mendelian Randomization studies
  18. Website(s)
  19. Website(s)
  20. Developed by
    Voight, Benjamin F., PhD
  21. Coded in
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Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016