MR_predictor

eagle-i ID

Resource Type

Properties

1. Resource Description

   "MR_predictor is a free, open-source simulation engine designed to guide the development and interpretation of statistical tests of causality between phenotypes using genetic instruments. MR_predictor provides a framework to model either individual traits or complex scenarios where multiple phenotypes are correlated or dependent on each other. MR_predictor can incorporate the effects of multiple, independent, biallelic loci contributing genotypic variability to one or more simulated phenotypes. The software has a range of options for sample generation, including ascertainment of a user-specified number cases under a disease model. The output files generated by MR_predictor port into commonly-used analysis tools (e.g., PLINK, R), facilitating a range of analyses germane for Mendelian Randomization studies. MR_predictor is currently implemented in PERL. The package is currently designed for the UNIX/Linux operating environment. MR_predictor is a development project by Benjamin F. Voight, Assistant Professor of Pharmacology and Genetics at the University of Pennsylvania – Perelman School of Medicine."

2. Used by

   Voight Laboratory

3. Operating System

   UNIX/Linux

4. Data Input

   genetic information file

5. Data Input

   phenotypic trait listing file

6. Data Input

   intermediate trait relationships summary file

7. Data Input

   intermediate trait to endpoint trait relationships summary file

8. Data Input

   genetic to trait relationship score file

9. Data Input

   haplotype information file to simulate linkage disequilibrium

10. Data Output

    Pedigree file

11. Data Output

    Map file

12. Data Output

    Phenotype file

13. Data Output

    Score file

14. Data Output

    Covariates file

15. Data Output

    LD summary files

16. Software purpose

    Population modeling objective

17. Related Publication or Documentation

    MR_predictor: a simulation engine for Mendelian Randomization studies

18. Website(s)

    http://coruscant.itmat.upenn.edu/mr_predictor/

19. Website(s)

    https://github.com/bvoight/mr_predictor

20. Developed by

    Voight, Benjamin F., Ph.D.

21. Coded in

    Perl