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MR_predictor
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000148-55af-7f58-6c8d-188780000000
Resource Type
Properties
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Resource Description
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"MR_predictor is a free, open-source simulation engine designed to guide the development and interpretation of statistical tests of causality between phenotypes using genetic instruments. MR_predictor provides a framework to model either individual traits or complex scenarios where multiple phenotypes are correlated or dependent on each other.
MR_predictor can incorporate the effects of multiple, independent, biallelic loci contributing genotypic variability to one or more simulated phenotypes. The software has a range of options for sample generation, including ascertainment of a user-specified number cases under a disease model. The output files generated by MR_predictor port into commonly-used analysis tools (e.g., PLINK, R), facilitating a range of analyses germane for Mendelian Randomization studies.
MR_predictor is currently implemented in PERL. The package is currently designed for the UNIX/Linux operating environment.
MR_predictor is a development project by Benjamin F. Voight, Assistant Professor of Pharmacology and Genetics at the University of Pennsylvania – Perelman School of Medicine."
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Used by
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Voight Laboratory
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Operating System
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UNIX/Linux
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Data Input
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genetic information file
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Data Input
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phenotypic trait listing file
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Data Input
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intermediate trait relationships summary file
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Data Input
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intermediate trait to endpoint trait relationships summary file
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Data Input
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genetic to trait relationship score file
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Data Input
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haplotype information file to simulate linkage disequilibrium
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Data Output
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Pedigree file
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Data Output
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Map file
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Data Output
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Phenotype file
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Data Output
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Score file
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Data Output
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Covariates file
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Data Output
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LD summary files
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Software purpose
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Population modeling objective
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Related Publication or Documentation
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MR_predictor: a simulation engine for Mendelian Randomization studies
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Website(s)
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http://coruscant.itmat.upenn.edu/mr_predictor/
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Website(s)
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https://github.com/bvoight/mr_predictor
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Developed by
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Voight, Benjamin F., PhD
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Coded in
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Perl
