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Mendelian Randomization pipeline

eagle-i ID


Resource Type

  1. Algorithmic software suite


  1. Resource Description
    "MeRP is a free, open-source tool designed to streamline and automate large-scale Mendelian Randomization analysis. There are three components of the MeRP pipeline. <strong>Pulling Genetic Instruments from Public Data</strong> • Pulls down and cleans most recent NHGRI Catalog of GWAS studies • Creates valid instrumental variable trait files (IVs) from catalog <strong>Filtering to satisfy MR conditions</strong> • Removes SNPs associated with potential confounding factors from IV file • Eliminates Linkage Disequilibrium (LD) within IV file. <strong>MR Calculator</strong> • Estimates causal effect of selected trait and preselected GWAS disease data"
  2. Additional Name
  3. Used by
    Voight Laboratory
  4. Data Input
    NHGRI GWAS catalog
  5. Data Input
    List of related traits in NHGRI catalog similar to trait of interest but not confounding
  6. Data Input
    List of column headers from pval_file potentially related to trait of interest
  7. Data Output
    Summary file with estimated causal effect, standard error on effect and p-value
  8. Data Output
    Individual SNP result file with estimated causal effect, standard error on effect and p-value
  9. Software purpose
    Population data analysis objective
  10. Related Publication or Documentation
    MeRP: a high-throughput pipeline for Mendelian randomization analysis
  11. Website(s)
  12. Related Technique
    Data analysis
  13. Developed by
    Voight, Benjamin F., PhD
  14. Coded in
Provenance Metadata About This Resource Record
  1. workflow state
  2. contributor
    ggrant (Gregory Grant)
  3. created
  4. creator
  5. modified
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016