Optical trap / Laser tweezers microscopes

eagle-i ID

Resource Type

Properties

1. Resource Description

   Optical tweezers microscopes for the measurement of nanometer-scale displacements and picoNewton-scale forces are available to Penn laboratories. These instruments are used for measuring biological forces (e.g., cell adhesion forces, protein-protein interactions, protein conformational changes, and other macromolecular associations) and manipulating objects in vitro and in the cytoplasm of live cells.

2. Contact

   Ostap, E. Michael., PhD

3. Access Restriction(s)

   Training by PMI faculty required.

4. Related Publication or Documentation

   Force Generation in Single Conventional Actomyosin Complexes under High Dynamic Load

5. Related Publication or Documentation

   Multi-step fibrinogen binding to the integrin (alpha)IIb(beta)3 detected using force spectroscopy

6. Related Publication or Documentation

   Myosin I Can Act As a Molecular Force Sensor

7. Developed by

   Pennsylvania Muscle Institute

8. Location

   Advanced Optical and Force Microscopy Facility (Penn)