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Tipe(-/-)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/0000014d-e843-ca00-5109-12c780000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Tipe<sup>−/−</sup> mice were generated using gene trap technology to target <i>Tipe</i> gene in B6 ES cells. The gene-trapping vector is composed of a viral long terminal repeat, a splice acceptor site, a Neomycin-resistant gene, and a polyA tail that stops <i>Tipe</i> gene transcription. This disrupted <i>Tipe</i> gene allele results in a complete loss of the short isoform of <i>Tipe</i> mRNA and a truncated long isoform of <i>Tipe</i> mRNA that encodes the first N-terminal 24 aa."
  2. Additional Name
    TIPE knock out
  3. Additional Name
    TNFAIP8-KO mice
  4. Access Restriction(s)
    No MTA restrictions
  5. Related Disease
    colitis
  6. Related Disease
    listeriosis
  7. Related Publication or Documentation
    Exacerbated Experimental Colitis in TNFAIP8-Deficient Mice
  8. Related Publication or Documentation
    Crucial Roles of TNFAIP8 Protein in Regulating Apoptosis and Listeria Infection
  9. Parental Strain Name
    C57BL/6
  10. Genetic Alteration(s)
    Tnfaip8(-/-)
  11. Developed by
    Youhai H. Chen Lab
  12. Phenotype Findings
    Normal developmental phenotype
  13. Phenotype Findings
    Hypersensitive to dextran sodium sulfate-induced colitis
  14. Phenotype Findings
    Resistance to <i>L. monocytogenes</i> infection
  15. Location
    Youhai H. Chen Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2015-06-12T11:00:48.500-04:00
  4. creator
    fcoldren
  5. modified
    2016-02-15T12:18:51.470-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016