Wnt7b(lacZ-/-)

eagle-i ID

Resource Type

Properties

1. Resource Description

   "A targeting vector was designed to replace exon 1, including the ATG, with a lacZ-neo cassette. Unexpectedly, transcripts contining exons 3 and 4 were detected at low levels. LacZ expression recapitulates the endogenous expression pattern."

2. Related Publication or Documentation

   Wnt7b regulates mesenchymal proliferation and vascular development in the lung

3. Related Publication or Documentation

   WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature

4. Related Publication or Documentation

   Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway

5. Related Publication or Documentation

   Wnt ligands signal in a cooperative manner to promote foregut organogenesis

6. Website(s)

   http://www.informatics.jax.org/allele/key/43705

7. Genetic Alteration(s)

   Wnt7b[tm1Eem]

8. Location

   Morrisey Lab