MDR

eagle-i ID

Resource Type

Properties

1. Related grant number

   AI59694

2. Related grant number

   LM009012

3. Resource Description

   "Multifactor Dimensionality Reduction (MDR) is a nonparametric and genetic model-free machine learning alternative to logistic regression for detecting and characterizing nonlinear interactions among discrete genetic and environmental attributes. The MDR method combines attribute selection, attribute construction, and classification with cross-validation and permutation testing to provide a comprehensive and powerful approach to detecting epistasis. MDR has been successfully applied to numerous different diseases and is currently being adapted to genome-wide association studies (GWAS)."

4. Additional Name

   Multifactor Dimensionality Reduction

5. Used by

   Computational Genetics Laboratory

6. Version

   3.0.2

7. Software purpose

   Molecular interaction network analysis objective

8. Related Publication or Documentation

   A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility

9. Website(s)

   http://www.epistasis.org/index-3.html

10. Website(s)

    http://www.multifactordimensionalityreduction.org

11. Related Technique

    Bioinformatics analysis

12. Software license

    GNU General Public License

13. Coded in

    Java