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MDR
eagle-i ID
http://eagle-i.itmat.upenn.edu/i/00000150-b534-2516-b538-857980000000
Resource Type
Properties
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Related grant number
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AI59694
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Related grant number
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LM009012
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Resource Description
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"Multifactor Dimensionality Reduction (MDR) is a nonparametric and genetic model-free machine learning alternative to logistic regression for detecting and characterizing nonlinear interactions among discrete genetic and environmental attributes. The MDR method combines attribute selection, attribute construction, and classification with cross-validation and permutation testing to provide a comprehensive and powerful approach to detecting epistasis. MDR has been successfully applied to numerous different diseases and is currently being adapted to genome-wide association studies (GWAS)."
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Additional Name
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Multifactor Dimensionality Reduction
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Used by
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Computational Genetics Laboratory
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Version
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3.0.2
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Software purpose
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Molecular interaction network analysis objective
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Related Publication or Documentation
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A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility
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Website(s)
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http://www.epistasis.org/index-3.html
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Website(s)
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http://www.multifactordimensionalityreduction.org
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Related Technique
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Bioinformatics analysis
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Software license
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GNU General Public License
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Coded in
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Java
