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TIPE2(-/-)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000152-e5f2-5392-64c8-c19180000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "Both exons of this gene locus were replaced by a neomycin resistance cassette. RT-PCR on bone marrow confirmed gene inactivation."
  2. Additional Name
    TIPE2 knock out
  3. Additional Name
    TIPE2-deficient mice
  4. Access Restriction(s)
    No MTA restrictions
  5. Related Publication or Documentation
    TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis
  6. Related Publication or Documentation
    TIPE2 protein prevents injury-induced restenosis in mice
  7. Related Publication or Documentation
    Enhanced atherosclerosis in TIPE2-deficient mice is associated with increased macrophage responses to oxidized low-density lipoprotein
  8. Related Publication or Documentation
    Critical roles of TIPE2 protein in murine experimental colitis
  9. Related Publication or Documentation
    TIPE2 protein serves as a negative regulator of phagocytosis and oxidative burst during infection
  10. Related Publication or Documentation
    TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway
  11. Related Publication or Documentation
    The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras
  12. Website(s)
    http://www.informatics.jax.org/allele/key/63895
  13. Parental Strain Name
    129
  14. Genetic Alteration(s)
    Tnfaip8l2[tm1Yhcn]
  15. Developed by
    Youhai H. Chen Lab
  16. Phenotype Findings
    normal gastrointestinal tract
  17. Phenotype Findings
    DSS-induced colitis resistant
  18. Phenotype Findings
    Resistant to bacterial infection
  19. Location
    Youhai H. Chen Lab
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2016-02-15T12:20:28.173-05:00
  4. creator
    fcoldren
  5. modified
    2016-02-15T12:20:33.806-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016