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DAF(-/-)

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000152-f14c-310f-4ae8-255580000000

Resource Type

  1. Mus musculus

Properties

  1. Exchange facilitator
    http://www.mmrrc.org/catalog/sds.php?mmrrc_id=30201
  2. Resource Description
    Mice were generated by gene targeting. "Exons 2 and 3, encoding the first and second short consensus repeats, were replaced with a neomycin selection cassette." Cryopreserved - no active mice
  3. Additional Name
    CD55<sup>-/-</sup>
  4. Additional Name
    DAF KO
  5. Additional Name
    DAF1<sup>-/-</sup>
  6. Related Disease
    glomerulonephritis
  7. Related Publication or Documentation
    Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
  8. Related Publication or Documentation
    Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor-deficient mice
  9. Related Publication or Documentation
    Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting
  10. Related Publication or Documentation
    The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo
  11. Related Publication or Documentation
    Decay-accelerating factor regulates T-cell immunity in the context of inflammation by influencing costimulatory molecule expression on antigen-presenting cells
  12. Related Publication or Documentation
    Blocking Properdin, the Alternative Pathway, and Anaphylatoxin Receptors Ameliorates Renal Ischemia-Reperfusion Injury in Decay-Accelerating Factor and CD59 Double-Knockout Mice
  13. Related Publication or Documentation
    Critical protection from renal ischemia reperfusion injury by CD55 and CD59
  14. Related Publication or Documentation
    Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack
  15. Related Publication or Documentation
    Absence of CD59 exacerbates systemic autoimmunity in MRL/lpr mice
  16. Related Publication or Documentation
    The membrane attack pathway of complement drives pathology in passively induced experimental autoimmune myasthenia gravis in mice
  17. Related Publication or Documentation
    Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo
  18. Related Publication or Documentation
    Deficiency of decay-accelerating factor and complement receptor 1–related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
  19. Related Publication or Documentation
    Complement-mediated clearance of erythrocytes: mechanism and delineation of the regulatory roles of Crry and DAF. Decay-accelerating factor
  20. Related Publication or Documentation
    Deletion of Crry and DAF on murine platelets stimulates thrombopoiesis and increases factor H-dependent resistance of peripheral platelets to complement attack
  21. Related Publication or Documentation
    Decay-accelerating factor 1 (Daf1) deficiency exacerbates xenobiotic-induced autoimmunity
  22. Related Publication or Documentation
    CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice
  23. Related Publication or Documentation
    Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry
  24. Related Publication or Documentation
    DAF/Crry double deficiency in mice exacerbates nephrotoxic serum-induced proteinuria despite markedly reduced systemic complement activity
  25. Related Publication or Documentation
    Retrovirus-mediated over-expression of decay-accelerating factor rescues Crry-deficient erythrocytes from acute alternative pathway complement attack
  26. Related Publication or Documentation
    Characterization of glycosylphosphatidylinositol-anchored decay accelerating factor (GPI-DAF) and transmembrane DAF gene expression in wild-type and GPI-DAF gene knockout mice using polyclonal and monoclonal antibodies with dual or single specificity
  27. Related Publication or Documentation
    Increased susceptibility of decay-accelerating factor deficient mice to anti-glomerular basement membrane glomerulonephritis
  28. Website(s)
    http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=8616
  29. Parental Strain Name
    Balb/c
  30. Biological process studied
    Immune system process
  31. Genetic Alteration(s)
    CD55[tm1Song]
  32. Phenotype Findings
    Impaired complement classical pathway
  33. Phenotype Findings
    Abnormal complement pathway
  34. Phenotype Findings
    Increased severity of experimental autoimmune encephalomyelitis
  35. Phenotype Findings
    Rescue of hyper T cell response
  36. Phenotype Findings
    Immune system phenotype
  37. Phenotype Findings
    Abnormal blood cells
  38. Phenotype Findings
    Response to acute LCMV infection
  39. Phenotype Findings
    Normal phenotype
  40. Phenotype Findings
    Hyperresponsive to LPS challenge
  41. Phenotype Findings
    Hyper T cell response to antigen restimulation
  42. Phenotype Findings
    Decreased grip strength
  43. Phenotype Findings
    Increased susceptibility to experimental autoimmune myasthenia gravis
  44. Phenotype Findings
    Hematopoietic system phenotype
  45. Phenotype Findings
    Increased susceptibility to nephrotoxic serum nephritis
  46. Phenotype Findings
    Abnormal macrophage morphology
  47. Phenotype Findings
    Impaired complement alternative pathway
  48. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2016-02-17T17:14:54.080-05:00
  4. creator
    fcoldren
  5. modified
    2016-02-17T17:16:03.120-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016