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KRN

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000152-f170-c544-4ae8-255580000000

Resource Type

  1. Mus musculus

Properties

  1. Resource Description
    "The sequences of the variable regions of the TCR alpha and beta chains of the R28 hybridoma with rearranged Va4Ja27 and Vb6Jb1.5 genomic DNA fragments were amplified and cloned into TCR expression cassettes. Transgene-derived clones are transcribed under the control of the natural TCR alpha and -beta promoter/enhancer elements. A single founder (KRN) in which TCRalpha and Tcrbeta transgenes were cointegrated was identified. These constructs together express a T cell receptor that recognizes the 41-61 peptide of bovine pancreas ribonuclease (RNase) in the context of A<sup>k</sup>." Diane Mathis developed original strain. This strain is cryo-preserved (NIH).
  2. Access Restriction(s)
    MTA restrictions
  3. Website(s)
    http://www.informatics.jax.org/allele/key/56231
  4. Parental Strain Name
    C57BL/6
  5. Genetic Alteration(s)
    Tg(TcraR28,TcrbR28)KRNDim
  6. Location
    Wen-Chao Song Laboratory
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2016-02-17T17:57:40.247-05:00
  4. creator
    fcoldren
  5. modified
    2016-02-18T14:01:33.419-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016