KRN

eagle-i ID

Resource Type

Properties

1. Resource Description

   "The sequences of the variable regions of the TCR alpha and beta chains of the R28 hybridoma with rearranged Va4Ja27 and Vb6Jb1.5 genomic DNA fragments were amplified and cloned into TCR expression cassettes. Transgene-derived clones are transcribed under the control of the natural TCR alpha and -beta promoter/enhancer elements. A single founder (KRN) in which TCRalpha and Tcrbeta transgenes were cointegrated was identified. These constructs together express a T cell receptor that recognizes the 41-61 peptide of bovine pancreas ribonuclease (RNase) in the context of A^k." Diane Mathis developed original strain. This strain is cryo-preserved (NIH).

2. Access Restriction(s)

   MTA restrictions

3. Website(s)

   http://www.informatics.jax.org/allele/key/56231

4. Parental Strain Name

   C57BL/6

5. Genetic Alteration(s)

   Tg(TcraR28,TcrbR28)KRNDim

6. Location

   Wen-Chao Song Laboratory