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Ryeom Laboratory

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000152-faee-4ca0-57b1-881380000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    "My laboratory is particularly interested in understanding how angiogenesis inhibitors act to limit endothelial cell activation and angiogenesis, and how they might be used therapeutically to treat cancers. Specific projects include: i) Understanding why Down syndrome individuals are protected against cancer and the role of the calcineurin inhibitor, DSCR1 in suppressing VEGF-mediated angiogenesis; ii) Identifying new cell extrinsic tumor suppressor functions of p53 and p19ARF: regulation of the endogenous angiogenesis inhibitors thrombopsondin-1 and endostatin; iii) Investigating a novel role for the endogenous angiogenesis inhibitor thrombospondin-1 in mediating oncogene-induced senescence; iv) Immune surveillance and the role of the endogenous angiogenesis inhibitors thrombospondin-1 and endostatin in tumor immunity."
  2. PI
    Ryeom, Sandra W., PhD
  3. Affiliation
    Department of Cancer Biology, University of Pennsylvania
  4. Website(s)
    http://www.cbio.med.upenn.edu/bioTemplate.asp?pageID=10
  5. Secondary affiliation
    Penn Institute for Immunology
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2016-02-19T14:08:01.097-05:00
  4. creator
    fcoldren
  5. modified
    2016-03-02T18:57:41.889-05:00
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016