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Speck Laboratory

eagle-i ID

http://eagle-i.itmat.upenn.edu/i/00000152-faf1-836b-57b1-881380000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    "The work in my laboratory is centered on the core binding factor (Runx1-CBFβ) and its roles in hematopoietic stem cell (HSC) formation and function. We study how HSCs form in the embryo, the step at which HSC formation is dependent on Runx1-CBFβ, the biochemical functions of Runx1-CBFβ, and how mutations in the genes encoding Runx1-CBFβ generate pre-leukemic stem cells. A more recent line of investigation is to determine the role of inflammatory signaling in HSC formation. "
  2. PI
    Speck, Nancy A., PhD
  3. Affiliation
    Department of Cell and Developmental Biology, University of Pennsylvania
  4. Website(s)
    http://www.med.upenn.edu/apps/faculty/index.php/g20001040/p8221581
  5. Secondary affiliation
    Penn Institute for Immunology
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    fcoldren
  3. created
    2016-02-19T14:11:30.683-05:00
  4. creator
    fcoldren
  5. modified
    2016-03-02T19:25:29.018-05:00
Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016